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Article

Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study

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Fetal Neonatal Neuroimaging and Developmental Science Center, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA
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Advanced Robotics and Human-Centred Technologies-CREO Lab, School of Engineering, University Campus Bio-Medico di Roma, 00128 Rome, Italy
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Division of Epilepsy and Clinical Neurophysiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Health Science Center, Department of Pediatrics and Neurology, Division of Peds Neurology, Le Bonheur Children’s Hospital, College of Medicine, University of Tennessee, Memphis, TN 38103, USA
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Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Epilepsy Surgery Program, Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Jane and John Justin Neurosciences Center, Cook Children’s Health Care System, Fort Worth, TX 76104, USA
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Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA
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Author to whom correspondence should be addressed.
Academic Editor: Dario Arnaldi
Diagnostics 2021, 11(7), 1234; https://doi.org/10.3390/diagnostics11071234
Received: 2 June 2021 / Revised: 29 June 2021 / Accepted: 5 July 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Brain Imaging in Epilepsy)
About 30% of children with drug-resistant epilepsy (DRE) continue to have seizures after epilepsy surgery. Since epilepsy is increasingly conceptualized as a network disorder, understanding how brain regions interact may be critical for planning re-operation in these patients. We aimed to estimate functional brain connectivity using scalp EEG and its evolution over time in patients who had repeated surgery (RS-group, n = 9) and patients who had one successful surgery (seizure-free, SF-group, n = 12). We analyzed EEGs without epileptiform activity at varying time points (before and after each surgery). We estimated functional connectivity between cortical regions and their relative centrality within the network. We compared the pre- and post-surgical centrality of all the non-resected (untouched) regions (far or adjacent to resection) for each group (using the Wilcoxon signed rank test). In alpha, theta, and beta frequency bands, the post-surgical centrality of the untouched cortical regions increased in the SF group (p < 0.001) whereas they decreased (p < 0.05) or did not change (p > 0.05) in the RS group after failed surgeries; when re-operation was successful, the post-surgical centrality of far regions increased (p < 0.05). Our data suggest that removal of the epileptogenic focus in children with DRE leads to a gain in the network centrality of the untouched areas. In contrast, unaltered or decreased connectivity is seen when seizures persist after surgery. View Full-Text
Keywords: electroencephalography; epilepsy; epilepsy surgery; functional connectivity; brain networks; children; source imaging; neuroimaging; clinical neurophysiology electroencephalography; epilepsy; epilepsy surgery; functional connectivity; brain networks; children; source imaging; neuroimaging; clinical neurophysiology
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MDPI and ACS Style

Iandolo, G.; Chourasia, N.; Ntolkeras, G.; Madsen, J.R.; Papadelis, C.; Grant, E.; Pearl, P.L.; Taffoni, F.; Tamilia, E. Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study. Diagnostics 2021, 11, 1234. https://doi.org/10.3390/diagnostics11071234

AMA Style

Iandolo G, Chourasia N, Ntolkeras G, Madsen JR, Papadelis C, Grant E, Pearl PL, Taffoni F, Tamilia E. Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study. Diagnostics. 2021; 11(7):1234. https://doi.org/10.3390/diagnostics11071234

Chicago/Turabian Style

Iandolo, Giulia, Nitish Chourasia, Georgios Ntolkeras, Joseph R. Madsen, Christos Papadelis, Ellen Grant, Phillip L. Pearl, Fabrizio Taffoni, and Eleonora Tamilia. 2021. "Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study" Diagnostics 11, no. 7: 1234. https://doi.org/10.3390/diagnostics11071234

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