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Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker
 
 
Article

Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms

1
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
2
Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany
3
Centre for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany
4
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
5
German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Joaquin Cubiella
Diagnostics 2021, 11(3), 561; https://doi.org/10.3390/diagnostics11030561
Received: 1 March 2021 / Revised: 15 March 2021 / Accepted: 18 March 2021 / Published: 20 March 2021
Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in metabolite concentrations between people with advanced colorectal neoplasms and those without neoplasms. Various types of bio-samples (plasma, feces, and urine) from 400 participants of screening colonoscopy were investigated using the MxP® Quant 500 kit (Biocrates, Innsbruck, Austria). We detected a broad range of metabolites in blood, stool, and urine samples (504, 331, and 131, respectively). Significant correlations were found between concentrations in blood and stool, blood and urine, and stool and urine for 93, 154, and 102 metabolites, of which 68 (73%), 126 (82%), and 39 (38%) were positive correlations. We found significant differences between participants with and without advanced colorectal neoplasms for concentrations of 123, 49, and 28 metabolites in blood, stool and urine samples, respectively. We detected mostly positive correlations between metabolite concentrations in blood samples and urine or stool samples, and mostly negative correlations between urine and stool samples. Differences between subjects with and without advanced colorectal neoplasms were found for metabolite concentrations in each of the three bio-fluids. View Full-Text
Keywords: metabolomics; liquid biopsy; colorectal neoplasms; urine; feces; plasma metabolomics; liquid biopsy; colorectal neoplasms; urine; feces; plasma
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MDPI and ACS Style

Erben, V.; Poschet, G.; Schrotz-King, P.; Brenner, H. Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms. Diagnostics 2021, 11, 561. https://doi.org/10.3390/diagnostics11030561

AMA Style

Erben V, Poschet G, Schrotz-King P, Brenner H. Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms. Diagnostics. 2021; 11(3):561. https://doi.org/10.3390/diagnostics11030561

Chicago/Turabian Style

Erben, Vanessa, Gernot Poschet, Petra Schrotz-King, and Hermann Brenner. 2021. "Comparing Metabolomics Profiles in Various Types of Liquid Biopsies among Screening Participants with and without Advanced Colorectal Neoplasms" Diagnostics 11, no. 3: 561. https://doi.org/10.3390/diagnostics11030561

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