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Article

Differential Expression of Anti-Inflammatory RNA Binding Proteins in Lupus Nephritis

1
Autoimmunity, Cancer, and Immunogenetics Research Laboratory, LR18SP12, University Hospital Habib Bourguiba of Sfax, Sfax 3000, Tunisia
2
Department of Immunology, Habib Bourguiba University Hospital, University of Sfax, Sfax 3000, Tunisia
3
Internal Medicine Department, Hedi Chaker University Hospital, University of Sfax, Sfax 3000, Tunisia
4
Renal Pathology Research Unit 12ES14, Nephrology Department, Faculty of Medicine of Sfax, Hedi Chaker University Hospital, Sfax 3000, Tunisia
5
Department of Pathology, LR18SP10, Habib Bourguiba University Hospital, Sfax 3000, Tunisia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Won Kim
Life 2022, 12(10), 1474; https://doi.org/10.3390/life12101474
Received: 11 August 2022 / Revised: 14 September 2022 / Accepted: 19 September 2022 / Published: 23 September 2022
Lupus nephritis (LN) is a type of immunological complex glomerulonephritis characterized by chronic renal inflammation which is exacerbated by infiltrating leukocytes and fueled by a variety of pro-inflammatory cytokines. A profound understanding of the pathogenesis of LN is necessary to identify the optimal molecular targets. The role of RNA-binding proteins (RBPs) in post-transcriptional gene regulation in the immune system is being explored in greater depth to better understand how this regulation is implicated in inflammatory and autoimmune diseases. Tristetraprolin (TTP), Roquin-1/2, and Regnase-1 are 3 RBPs that play a critical role in the regulation of pro-inflammatory mediators by gating the degradation and/or translational silencing of target mRNAs. In this study, we proposed to focus on the differential expression of these RBPs in immune cells and renal biopsies from LN patients, as well as their regulatory impact on a specific target. Herein, we highlight a novel target of anti-inflammatory treatment by revealing the mechanisms underlying RBP expression and the interaction between RBPs and their target RNAs. View Full-Text
Keywords: lupus nephritis; RNA binding protein; cytokines lupus nephritis; RNA binding protein; cytokines
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MDPI and ACS Style

Fakhfakh, R.; Bouallegui, E.; Houssaini, H.; Elloumi, N.; Dhafouli, F.; Abida, O.; Hachicha, H.; Marzouk, S.; Bahloul, Z.; Kammoun, K.; Boudawara, T.; Masmoudi, H. Differential Expression of Anti-Inflammatory RNA Binding Proteins in Lupus Nephritis. Life 2022, 12, 1474. https://doi.org/10.3390/life12101474

AMA Style

Fakhfakh R, Bouallegui E, Houssaini H, Elloumi N, Dhafouli F, Abida O, Hachicha H, Marzouk S, Bahloul Z, Kammoun K, Boudawara T, Masmoudi H. Differential Expression of Anti-Inflammatory RNA Binding Proteins in Lupus Nephritis. Life. 2022; 12(10):1474. https://doi.org/10.3390/life12101474

Chicago/Turabian Style

Fakhfakh, Raouia, Emna Bouallegui, Hana Houssaini, Nesrine Elloumi, Fatma Dhafouli, Olfa Abida, Hend Hachicha, Sameh Marzouk, Zouhir Bahloul, Khawla Kammoun, Tahia Boudawara, and Hatem Masmoudi. 2022. "Differential Expression of Anti-Inflammatory RNA Binding Proteins in Lupus Nephritis" Life 12, no. 10: 1474. https://doi.org/10.3390/life12101474

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