Next Article in Journal
VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins
Previous Article in Journal
Antibody Conjugates: From Heterogeneous Populations to Defined Reagents
Review

B Cell Epitope-Based Vaccination Therapy

1
Department of Molecular Life Science, Tokai University School of Medicine, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
2
Department of Breast and Endocrine Surgery, Tokai University School of Medicine, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Helmout Modjtahedi
Antibodies 2015, 4(3), 225-239; https://doi.org/10.3390/antib4030225
Received: 13 March 2015 / Revised: 31 July 2015 / Accepted: 7 August 2015 / Published: 14 August 2015
Currently, many peptide vaccines are undergoing clinical studies. Most of these vaccines were developed to activate cytotoxic T cells; however, the response is not robust. Unlike vaccines, anti-cancer antibodies based on passive immunity have been approved as a standard treatment. Since passive immunity is more effective in tumor treatment, the evidence suggests that limited B cell epitope-based peptide vaccines may have similar activity. Nevertheless, such peptide vaccines have not been intensively developed primarily because humoral immunity is thought to be preferable to cancer progression. B cells secrete cytokines, which suppress immune functions. This review discusses the possibility of therapeutic antibody induction by a peptide vaccine and the role of active and passive B cell immunity in cancer patients. We also discuss the use of humanized mice as a pre-clinical model. The necessity of a better understanding of the activity of B cells in cancer is also discussed. View Full-Text
Keywords: cancer vaccine; passive immunity; B cell epitope cancer vaccine; passive immunity; B cell epitope
Show Figures

Figure 1

MDPI and ACS Style

Kametani, Y.; Miyamoto, A.; Tsuda, B.; Tokuda, Y. B Cell Epitope-Based Vaccination Therapy. Antibodies 2015, 4, 225-239. https://doi.org/10.3390/antib4030225

AMA Style

Kametani Y, Miyamoto A, Tsuda B, Tokuda Y. B Cell Epitope-Based Vaccination Therapy. Antibodies. 2015; 4(3):225-239. https://doi.org/10.3390/antib4030225

Chicago/Turabian Style

Kametani, Yoshie, Asuka Miyamoto, Banri Tsuda, and Yutaka Tokuda. 2015. "B Cell Epitope-Based Vaccination Therapy" Antibodies 4, no. 3: 225-239. https://doi.org/10.3390/antib4030225

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop