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Genes 2017, 8(12), 366;

Current Research on Non-Coding Ribonucleic Acid (RNA)

Department of Biostatistics, Vanderbilt University, Medical Center, Nashville, TN 37232, USA
Department of Molecular Physiology and Biophysics, Vanderbilt Genetics Institute, Vanderbilt University Medical School, Nashville, TN 37232, USA
Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China
Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87102, USA
Author to whom correspondence should be addressed.
Received: 13 October 2017 / Revised: 16 November 2017 / Accepted: 21 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Non-coding RNAs)
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Non-coding ribonucleic acid (RNA) has without a doubt captured the interest of biomedical researchers. The ability to screen the entire human genome with high-throughput sequencing technology has greatly enhanced the identification, annotation and prediction of the functionality of non-coding RNAs. In this review, we discuss the current landscape of non-coding RNA research and quantitative analysis. Non-coding RNA will be categorized into two major groups by size: long non-coding RNAs and small RNAs. In long non-coding RNA, we discuss regular long non-coding RNA, pseudogenes and circular RNA. In small RNA, we discuss miRNA, transfer RNA, piwi-interacting RNA, small nucleolar RNA, small nuclear RNA, Y RNA, single recognition particle RNA, and 7SK RNA. We elaborate on the origin, detection method, and potential association with disease, putative functional mechanisms, and public resources for these non-coding RNAs. We aim to provide readers with a complete overview of non-coding RNAs and incite additional interest in non-coding RNA research. View Full-Text
Keywords: long non-coding RNA; small RNA; detection; functional mechanism; disease; resource long non-coding RNA; small RNA; detection; functional mechanism; disease; resource

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Wang, J.; Samuels, D.C.; Zhao, S.; Xiang, Y.; Zhao, Y.-Y.; Guo, Y. Current Research on Non-Coding Ribonucleic Acid (RNA). Genes 2017, 8, 366.

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