Next Article in Journal / Special Issue
Genes and Genetic Testing in Hereditary Ataxias
Previous Article in Journal / Special Issue
An Efficient Estimator of the Mutation Parameter and Analysis of Polymorphism from the 1000 Genomes Project
Article Menu

Export Article

Open AccessReview
Genes 2014, 5(3), 576-585;

The Challenges of Genome Analysis in the Health Care Setting

Clinical Ethics and Law Unit, Wessex Clinical Genetics Service, The Princess Anne Hospital, Southampton, SO16 5YA, UK
Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Author to whom correspondence should be addressed.
Received: 27 May 2014 / Revised: 4 July 2014 / Accepted: 7 July 2014 / Published: 22 July 2014
(This article belongs to the Special Issue Grand Celebration: 10th Anniversary of the Human Genome Project)
Full-Text   |   PDF [75 KB, uploaded 22 July 2014]


Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice. View Full-Text
Keywords: genome sequencing; clinical practice; incidental findings; consent; disclosure genome sequencing; clinical practice; incidental findings; consent; disclosure
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Lucassen, A.; Houlston, R.S. The Challenges of Genome Analysis in the Health Care Setting. Genes 2014, 5, 576-585.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top