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From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer

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Department of Surgery, Tom Baker Cancer Center, University of Calgary, 1331 29th St NW, Calgary, AB T2N 4N2, Canada
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Department of Oncology, Tom Baker Cancer Center, University of Calgary, 1331 29th St NW, Calgary, AB T2N 4N2, Canada
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Author to whom correspondence should be addressed.
Genes 2014, 5(3), 536-560; https://doi.org/10.3390/genes5030536
Received: 18 March 2014 / Revised: 27 May 2014 / Accepted: 27 June 2014 / Published: 22 July 2014
(This article belongs to the Special Issue Grand Celebration: 10th Anniversary of the Human Genome Project)
Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor. View Full-Text
Keywords: metabolomics; colorectal cancer; functional genomics metabolomics; colorectal cancer; functional genomics
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Bathe, O.F.; Farshidfar, F. From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer. Genes 2014, 5, 536-560.

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