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Clinical Experiences with Radiation Induced Thyroid Cancer after Chernobyl
Open AccessArticle

Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia

1
Institute of Clinical Radiology, Research Centre for Radiation Medicine, 53 Melnikova, 04050 Kyiv, Ukraine
2
Institute of Pathology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
3
Institute of Radiobiology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
4
Clinical Cooperation Group Osteosarcoma, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health and Department of Pediatrics, Technische Universitaet Muenchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2011, 2(2), 384-393; https://doi.org/10.3390/genes2020384
Received: 6 April 2011 / Revised: 18 May 2011 / Accepted: 27 May 2011 / Published: 31 May 2011
(This article belongs to the Special Issue Radiation-Related Cancer 25 Years After Chernobyl)
Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases. View Full-Text
Keywords: acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray
MDPI and ACS Style

Klymenko, S.V.; Smida, J.; Atkinson, M.J.; Bebeshko, V.G.; Nathrath, M.; Rosemann, M. Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia. Genes 2011, 2, 384-393.

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