Next Article in Journal
Maternal Uniparental Disomy of Chromosome 20 (UPD(20)mat) as Differential Diagnosis of Silver Russell Syndrome: Identification of Three New Cases
Previous Article in Journal
Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales
Open AccessReview

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review

1
Stem Cell Laboratory, Center for Bone Marrow Transplants, Brazilian National Cancer Institute—INCA, Rio de Janeiro 20230-240, Brazil
2
Stricto Sensu Graduate Program in Oncology, INCA, Rio de Janeiro 20230-240, Brazil
3
Laboratory of Cellular and Molecular Hemato-Oncology, Molecular Hemato-Oncology Program, Brazilian National Cancer Institute—INCA, Rio de Janeiro 20230-240, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Mariarosa Anna Beatrice Melone and Sujoy Ghosh
Genes 2021, 12(4), 587; https://doi.org/10.3390/genes12040587
Received: 21 March 2021 / Revised: 8 April 2021 / Accepted: 15 April 2021 / Published: 17 April 2021
(This article belongs to the Section Human Genomics and Genetic Diseases)
Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid and is involved in many essential biochemical processes. Dietary folate is converted into tetrahydrofolate, a vital methyl donor for most methylation reactions, including DNA methylation. 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. MTHFR polymorphisms result in reduced enzyme activity and altered levels of DNA methylation and synthesis. MTHFR polymorphisms have been linked to increased risks of several pathologies, including cancer. Breast cancer, gliomas and gastric cancer are highly heterogeneous and aggressive diseases associated with high mortality rates. The impact of MTHFR polymorphisms on these tumors remains controversial in the literature. This review discusses the relationship between the MTHFR C677T and A1298C polymorphisms and the increased risk of breast cancer, gliomas, and gastric cancer. Additionally, we highlight the relevance of ethnic and dietary aspects of population-based studies and histological stratification of highly heterogeneous tumors. Finally, this review discusses these aspects as potential factors responsible for the controversial literature concerning MTHFR polymorphisms. View Full-Text
Keywords: polymorphism; MTHFR; breast cancer; glioma; gastric cancer polymorphism; MTHFR; breast cancer; glioma; gastric cancer
Show Figures

Figure 1

MDPI and ACS Style

Petrone, I.; Bernardo, P.S.; dos Santos, E.C.; Abdelhay, E. MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review. Genes 2021, 12, 587. https://doi.org/10.3390/genes12040587

AMA Style

Petrone I, Bernardo PS, dos Santos EC, Abdelhay E. MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review. Genes. 2021; 12(4):587. https://doi.org/10.3390/genes12040587

Chicago/Turabian Style

Petrone, Igor; Bernardo, Paula S.; dos Santos, Everton C.; Abdelhay, Eliana. 2021. "MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review" Genes 12, no. 4: 587. https://doi.org/10.3390/genes12040587

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop