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Article

Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract through Transcriptome Profiling

1
Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
2
Anti-Aging Research Institute of BIO-FD&C Co., Ltd., Incheon 21990, Korea
3
Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
Genes 2020, 11(2), 230; https://doi.org/10.3390/genes11020230
Received: 17 January 2020 / Revised: 18 February 2020 / Accepted: 20 February 2020 / Published: 21 February 2020
(This article belongs to the Section Molecular Genetics and Genomics)
Edelweiss (Leontopodium Alpinum) in the family Asteraceae is a wildflower that grows in rocky limestone places. Here, we investigated the efficacy of edelweiss callus culture extract (Leontopodium Alpinum callus culture extract; LACCE) using multiple assays from in vitro to in vivo as well as transcriptome profiling. Several in vitro assay results showed the strong antioxidant activity of LACCE in response to UVB treatment. Moreover, LACCE suppressed inflammation and wrinkling; however, moisturizing activity was increased by LACCE. The clinical test in vivo demonstrated that constant application of LACCE on the face and skin tissues improved anti-periorbital wrinkles, skin elasticity, dermal density, and skin thickness compared with the placebo. The RNA-Sequencing results showed at least 16.56% of human genes were expressed in keratinocyte cells. LACCE up-regulated genes encoding several KRT proteins; DDIT4, BNIP3, and IGFBP3 were involved in the positive regulation of the developmental process, programmed cell death, keratinization, and cornification forming skin barriers, which provide many advantages in the human skin. By contrast, down-regulated genes were stress-responsive genes, including metal, oxidation, wounding, hypoxia, and virus infection, suggesting LACCE did not cause any harmful stress on the skin. Our comprehensive study demonstrated LACCE is a promising agent for anti-aging cosmetics. View Full-Text
Keywords: anti-aging; callus; edelweiss; skin cells; transcriptome anti-aging; callus; edelweiss; skin cells; transcriptome
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MDPI and ACS Style

Cho, W.K.; Kim, H.-I.; Kim, S.-Y.; Seo, H.H.; Song, J.; Kim, J.; Shin, D.S.; Jo, Y.; Choi, H.; Lee, J.H.; Moh, S.H. Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract through Transcriptome Profiling. Genes 2020, 11, 230. https://doi.org/10.3390/genes11020230

AMA Style

Cho WK, Kim H-I, Kim S-Y, Seo HH, Song J, Kim J, Shin DS, Jo Y, Choi H, Lee JH, Moh SH. Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract through Transcriptome Profiling. Genes. 2020; 11(2):230. https://doi.org/10.3390/genes11020230

Chicago/Turabian Style

Cho, Won K., Hye-In Kim, Soo-Yun Kim, Hyo H. Seo, Jihyeok Song, Jiyeon Kim, Dong S. Shin, Yeonhwa Jo, Hoseong Choi, Jeong H. Lee, and Sang H. Moh 2020. "Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract through Transcriptome Profiling" Genes 11, no. 2: 230. https://doi.org/10.3390/genes11020230

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