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Open AccessFeature PaperReview

Genome Organization in and around the Nucleolus

1
Department of Molecular Mechanisms of Disease, DMMD, University of Zurich, 8057 Zurich, Switzerland
2
Molecular Life Science Program, Life Science Zurich Graduate School, University of Zurich, 8057 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 579; https://doi.org/10.3390/cells8060579
Received: 23 April 2019 / Revised: 9 June 2019 / Accepted: 11 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Nucleolar Organization and Functions in Health and Disease)
The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal RNA (rRNA) genes. Each cell contains hundreds of rRNA genes, which are organized in three distinct chromatin and transcriptional states—silent, inactive and active. Increasing evidence indicates that the role of the nucleolus and rRNA genes goes beyond the control of ribosome biogenesis. Recent results highlighted the nucleolus as a compartment for the location and regulation of repressive genomic domains and, together with the nuclear lamina, represents the hub for the organization of the inactive heterochromatin. In this review, we aim to describe the crosstalk between the nucleolus and the rest of the genome and how distinct rRNA gene chromatin states affect nucleolus structure and are implicated in genome stability, genome architecture, and cell fate decision. View Full-Text
Keywords: Nucleolus; rRNA genes; NoRC; chromatin; epigenetics; lncRNA; nucleolus-associated domains (NADs); lamina-associated domains(LADs); genome architecture; genome instability; embryonic stem cells; cancer Nucleolus; rRNA genes; NoRC; chromatin; epigenetics; lncRNA; nucleolus-associated domains (NADs); lamina-associated domains(LADs); genome architecture; genome instability; embryonic stem cells; cancer
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Bersaglieri, C.; Santoro, R. Genome Organization in and around the Nucleolus. Cells 2019, 8, 579.

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