Mitochondrial DNA Integrity: Role in Health and Disease
AbstractAs the primary cellular location for respiration and energy production, mitochondria serve in a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique features of this organelle, its distinct genome. Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development of both severe early-onset maladies and chronic age-related diseases. In this article, we review the processes by which mtDNA integrity is maintained, with an emphasis on the repair of oxidative DNA lesions, and the cellular consequences of diminished mitochondrial genome stability. View Full-Text
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Sharma, P.; Sampath, H. Mitochondrial DNA Integrity: Role in Health and Disease. Cells 2019, 8, 100.
Sharma P, Sampath H. Mitochondrial DNA Integrity: Role in Health and Disease. Cells. 2019; 8(2):100.Chicago/Turabian Style
Sharma, Priyanka; Sampath, Harini. 2019. "Mitochondrial DNA Integrity: Role in Health and Disease." Cells 8, no. 2: 100.
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