Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
Abstract
:1. Introduction
2. Cancers Controlled by TBK1 and/or IKKε
3. Control of IKKε and TBK1, and Downstream Signaling
4. Subcellular Localization and Target Specificity
5. TBK1 and Mitosis
6. Autophagy Regulation by TBK1
7. Promotion of KRAS-Induced Oncogenesis and Control of Akt
8. TBK1 and IKKε Control of mTORC1 and Metabolism
9. TBK1 and Antitumor Immunity
10. DNA Damage and Cancer: Is TBK1 Involved?
11. Therapeutic Potential and Future Considerations
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Biological Process | Kinase | Substrate | Protein Function |
---|---|---|---|
Immune response/inflammation | TBK1 | Act1 | E3 ubiquitin ligase |
cRel | transcription factor | ||
IRF3 | transcription factor | ||
IRF7 | transcription factor | ||
NFATc1 | transcription factor | ||
RelA/p65 | transcription factor | ||
PELI1 | E3 ubiquitin ligase | ||
STAT3 | transcription factor | ||
STAT6 | transcription factor | ||
STING | receptor/adaptor | ||
TANK | adaptor | ||
TRAF2 | E3 ubiquitin ligase | ||
XIAP | E3 ubiquitin ligase | ||
IKKε | c-Jun | transcription factor | |
Autophagy | TBK1 | OPTN | autophagy receptor |
p62 | autophagy receptor | ||
Proliferation/growth | TBK1 | Akt | kinase |
CEP170 | centrosome associated protein | ||
CYLD | deubiquitinase | ||
mTOR | kinase | ||
NuMA | centrosome associated protein | ||
PLK | centrosome associated protein | ||
Sec5 | exocyst component | ||
Insulin signaling | TBK1 | IR | receptor kinase |
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Durand, J.K.; Zhang, Q.; Baldwin, A.S. Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer. Cells 2018, 7, 139. https://doi.org/10.3390/cells7090139
Durand JK, Zhang Q, Baldwin AS. Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer. Cells. 2018; 7(9):139. https://doi.org/10.3390/cells7090139
Chicago/Turabian StyleDurand, Joel K., Qing Zhang, and Albert S. Baldwin. 2018. "Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer" Cells 7, no. 9: 139. https://doi.org/10.3390/cells7090139