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Cells 2018, 7(6), 62;

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Author to whom correspondence should be addressed.
Received: 11 May 2018 / Revised: 11 June 2018 / Accepted: 14 June 2018 / Published: 15 June 2018
(This article belongs to the Special Issue TRP Channels in Health and Disease)
Full-Text   |   PDF [281 KB, uploaded 15 June 2018]


The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology. View Full-Text
Keywords: TRPM4 channel; cardiovascular system; physiology; pathophysiology TRPM4 channel; cardiovascular system; physiology; pathophysiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, C.; Naruse, K.; Takahashi, K. Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology. Cells 2018, 7, 62.

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