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TRPV1: A Potential Drug Target for Treating Various Diseases

1
Department of Pharmacology and Neuroscience, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
2
Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Niteroi 24020141, RJ, Brazil
3
Department of Surgery (Otoloryngalogy), Southern Illinois University School of Medicine, Springfield, IL 62702, USA
*
Author to whom correspondence should be addressed.
Cells 2014, 3(2), 517-545; https://doi.org/10.3390/cells3020517
Received: 27 March 2014 / Revised: 14 May 2014 / Accepted: 15 May 2014 / Published: 23 May 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. As such, TRPV1 serves as a multimodal sensor of noxious stimuli which could trigger counteractive measures to avoid pain and injury. Activation of TRPV1 has been linked to chronic inflammatory pain conditions and peripheral neuropathy, as observed in diabetes. Expression of TRPV1 is also observed in non-neuronal sites such as the epithelium of bladder and lungs and in hair cells of the cochlea. At these sites, activation of TRPV1 has been implicated in the pathophysiology of diseases such as cystitis, asthma and hearing loss. Therefore, drugs which could modulate TRPV1 channel activity could be useful for the treatment of conditions ranging from chronic pain to hearing loss. This review describes the roles of TRPV1 in the normal physiology and pathophysiology of selected organs of the body and highlights how drugs targeting this channel could be important clinically. View Full-Text
Keywords: TRPV1; peripheral neuropathy; ototoxicity; diabetes; cystitis; obesity TRPV1; peripheral neuropathy; ototoxicity; diabetes; cystitis; obesity
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Brito, R.; Sheth, S.; Mukherjea, D.; Rybak, L.P.; Ramkumar, V. TRPV1: A Potential Drug Target for Treating Various Diseases. Cells 2014, 3, 517-545.

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