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Article

Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation

Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59 Street, 80-308 Gdansk, Poland
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Author to whom correspondence should be addressed.
Cells 2025, 14(15), 1189; https://doi.org/10.3390/cells14151189 (registering DOI)
Submission received: 3 July 2025 / Revised: 25 July 2025 / Accepted: 31 July 2025 / Published: 1 August 2025
(This article belongs to the Section Cells of the Nervous System)

Abstract

(1) Insulin-like growth factor-1 (IGF-1) is a neurotrophin with anti-inflammatory properties. Neuroinflammation and stress activate peripheral immune mechanisms, which may contribute to the development of depression and anxiety in sporadic Alzheimer’s disease (sAD). This study aims to evaluate whether intracerebroventricular (ICV) premedication with IGF-1 in a rat model of streptozotocin (STZ)-induced neuroinflammation can prevent the emergence of anhedonia and anxiety-like behavior by impacting the peripheral inflammatory responses. (2) Male Wistar rats were subjected to double ICVSTZ (total dose: 3 mg/kg) and ICVIGF-1 injections (total dose: 2 µg). We analyzed the level of anhedonia (sucrose preference), anxiety (elevated plus maze), peripheral inflammation (hematological and cytometric measurement of leukocyte populations, interleukin (IL)-6), and corticosterone concentration at 7 (very early stage, VES), 45 (early stage, ES), and 90 days after STZ injections (late stage, LS). (3) We found that ICVIGF-1 administration reduces behavioral symptoms: anhedonia (ES and LS) and anxiety (VES, ES), and peripheral inflammation: number of leukocytes, lymphocytes, T lymphocytes, monocytes, granulocytes, IL-6, and corticosterone concentration (LS) in the rat model of sAD. (4) The obtained results demonstrate beneficial effects of central IGF-1 administration on neuropsychiatric symptoms and peripheral immune system activation during disease progression in the rat model of sAD.
Keywords: sporadic Alzheimer’s disease model; insulin-like growth factor-1; anhedonia; anxiety; peripheral inflammation sporadic Alzheimer’s disease model; insulin-like growth factor-1; anhedonia; anxiety; peripheral inflammation

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MDPI and ACS Style

Dunacka, J.; Grembecka, B.; Wrona, D. Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation. Cells 2025, 14, 1189. https://doi.org/10.3390/cells14151189

AMA Style

Dunacka J, Grembecka B, Wrona D. Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation. Cells. 2025; 14(15):1189. https://doi.org/10.3390/cells14151189

Chicago/Turabian Style

Dunacka, Joanna, Beata Grembecka, and Danuta Wrona. 2025. "Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation" Cells 14, no. 15: 1189. https://doi.org/10.3390/cells14151189

APA Style

Dunacka, J., Grembecka, B., & Wrona, D. (2025). Central Insulin-Like Growth Factor-1-Induced Anxiolytic and Antidepressant Effects in a Rat Model of Sporadic Alzheimer’s Disease Are Associated with the Peripheral Suppression of Inflammation. Cells, 14(15), 1189. https://doi.org/10.3390/cells14151189

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