Next Article in Journal
The Effect of Normoxic and Hypoxic U-87 Glioblastoma Paracrine Secretion on the Modulation of Brain Endothelial Cells
Next Article in Special Issue
Implication of Adult Hippocampal Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches
Previous Article in Journal
Theoretical Concepts in Magnetobiology after 40 Years of Research
Previous Article in Special Issue
Sensorimotor Rehabilitation Promotes Vestibular Compensation in a Rodent Model of Acute Peripheral Vestibulopathy by Promoting Microgliogenesis in the Deafferented Vestibular Nuclei

Multifaceted Microcephaly-Related Gene MCPH1

Leibniz Institute on Aging—Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745 Jena, Germany
Faculty of Biological Sciences, Friedrich-Schiller University of Jena, Bachstrasse 18k, 07743 Jena, Germany
Author to whom correspondence should be addressed.
Academic Editor: Luisa Alexandra Meireles Pinto
Cells 2022, 11(2), 275;
Received: 19 December 2021 / Revised: 11 January 2022 / Accepted: 12 January 2022 / Published: 14 January 2022
(This article belongs to the Special Issue Frontiers in Neurogenesis)
MCPH1, or BRIT1, is often mutated in human primary microcephaly type 1, a neurodevelopmental disorder characterized by a smaller brain size at birth, due to its dysfunction in regulating the proliferation and self-renewal of neuroprogenitor cells. In the last 20 years or so, genetic and cellular studies have identified MCPH1 as a multifaceted protein in various cellular functions, including DNA damage signaling and repair, the regulation of chromosome condensation, cell-cycle progression, centrosome activity and the metabolism. Yet, genetic and animal model studies have revealed an unpredicted essential function of MPCH1 in gonad development and tumorigenesis, although the underlying mechanism remains elusive. These studies have begun to shed light on the role of MPCH1 in controlling various pathobiological processes of the disorder. Here, we summarize the biological functions of MCPH1, and lessons learnt from cellular and mouse models of MCPH1. View Full-Text
Keywords: MCPH; neurogenesis; gonad development; tumorigenesis; mouse models MCPH; neurogenesis; gonad development; tumorigenesis; mouse models
Show Figures

Graphical abstract

MDPI and ACS Style

Kristofova, M.; Ori, A.; Wang, Z.-Q. Multifaceted Microcephaly-Related Gene MCPH1. Cells 2022, 11, 275.

AMA Style

Kristofova M, Ori A, Wang Z-Q. Multifaceted Microcephaly-Related Gene MCPH1. Cells. 2022; 11(2):275.

Chicago/Turabian Style

Kristofova, Martina, Alessandro Ori, and Zhao-Qi Wang. 2022. "Multifaceted Microcephaly-Related Gene MCPH1" Cells 11, no. 2: 275.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop