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Circadian Organelles: Rhythms at All Scales

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel
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Author to whom correspondence should be addressed.
Academic Editors: Paolo Bernardi, Luca Scorrano and Gerardo Z. Lederkremer
Cells 2021, 10(9), 2447; https://doi.org/10.3390/cells10092447
Received: 29 August 2021 / Revised: 14 September 2021 / Accepted: 14 September 2021 / Published: 16 September 2021
(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Organelle Function)
Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summarize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Finally, we discuss the importance and challenges faced by spatio-temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of communication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier. View Full-Text
Keywords: circadian clocks; rhythms; organelles; mitochondria; nucleus; endoplasmic reticulum; lysosomes circadian clocks; rhythms; organelles; mitochondria; nucleus; endoplasmic reticulum; lysosomes
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MDPI and ACS Style

Aviram, R.; Adamovich, Y.; Asher, G. Circadian Organelles: Rhythms at All Scales. Cells 2021, 10, 2447. https://doi.org/10.3390/cells10092447

AMA Style

Aviram R, Adamovich Y, Asher G. Circadian Organelles: Rhythms at All Scales. Cells. 2021; 10(9):2447. https://doi.org/10.3390/cells10092447

Chicago/Turabian Style

Aviram, Rona, Yaarit Adamovich, and Gad Asher. 2021. "Circadian Organelles: Rhythms at All Scales" Cells 10, no. 9: 2447. https://doi.org/10.3390/cells10092447

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