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Review

Acetylation in Mitochondria Dynamics and Neurodegeneration

1
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2
Veterans Affairs Maryland Health Center System, 10 North Greene Street, Baltimore, MD 21201, USA
3
Department of Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research (S.T.A.R.), University of Maryland School of Medicine, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Paolo Bernardi, Luca Scorrano and Gerardo Z. Lederkremer
Cells 2021, 10(11), 3031; https://doi.org/10.3390/cells10113031
Received: 27 September 2021 / Revised: 3 November 2021 / Accepted: 3 November 2021 / Published: 5 November 2021
(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Organelle Function)
Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively moving, dividing, or fusing. This process of mitochondrial dynamics is fine-tuned by a specific group of proteins and their complex post-translational modifications. In this review, we discuss the mitochondrial dynamics regulatory enzymes, their adaptor proteins, and the effect of acetylation on the activity of fusion and fission machinery as a ubiquitous response to metabolic stresses. Further, we discuss the role of intracellular cytoskeleton structures and their post-translational modifications in the modulation of mitochondrial fusion and fission. Finally, we review the role of mitochondrial dynamics dysregulation in the pathophysiology of acute brain injury and the treatment strategies based on modulation of NAD+-dependent deacetylation. View Full-Text
Keywords: mitochondria; dynamics; tubulin; acetylation mitochondria; dynamics; tubulin; acetylation
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MDPI and ACS Style

Waddell, J.; Banerjee, A.; Kristian, T. Acetylation in Mitochondria Dynamics and Neurodegeneration. Cells 2021, 10, 3031. https://doi.org/10.3390/cells10113031

AMA Style

Waddell J, Banerjee A, Kristian T. Acetylation in Mitochondria Dynamics and Neurodegeneration. Cells. 2021; 10(11):3031. https://doi.org/10.3390/cells10113031

Chicago/Turabian Style

Waddell, Jaylyn, Aditi Banerjee, and Tibor Kristian. 2021. "Acetylation in Mitochondria Dynamics and Neurodegeneration" Cells 10, no. 11: 3031. https://doi.org/10.3390/cells10113031

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