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Communication

Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

by
Mary Ecke
,
Jana Prassler
and
Günther Gerisch
*
Cell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, Germany
*
Author to whom correspondence should be addressed.
Cells 2021, 10(9), 2240; https://doi.org/10.3390/cells10092240
Submission received: 26 July 2021 / Revised: 20 August 2021 / Accepted: 24 August 2021 / Published: 29 August 2021
(This article belongs to the Special Issue Comparative Biology of Microtubule Organization in Eukaryotes)
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Abstract

Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.
Keywords: centrosomes; chromosome segregation; Dictyostelium; genetic instability; mitosis; multinucleate cells centrosomes; chromosome segregation; Dictyostelium; genetic instability; mitosis; multinucleate cells

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MDPI and ACS Style

Ecke, M.; Prassler, J.; Gerisch, G. Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells 2021, 10, 2240. https://doi.org/10.3390/cells10092240

AMA Style

Ecke M, Prassler J, Gerisch G. Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells. 2021; 10(9):2240. https://doi.org/10.3390/cells10092240

Chicago/Turabian Style

Ecke, Mary, Jana Prassler, and Günther Gerisch. 2021. "Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium" Cells 10, no. 9: 2240. https://doi.org/10.3390/cells10092240

APA Style

Ecke, M., Prassler, J., & Gerisch, G. (2021). Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells, 10(9), 2240. https://doi.org/10.3390/cells10092240

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