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Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease

Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA
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Academic Editors: Gabriella Minchiotti and Annalisa Fico
Cells 2021, 10(8), 2045; https://doi.org/10.3390/cells10082045
Received: 15 June 2021 / Revised: 23 July 2021 / Accepted: 3 August 2021 / Published: 10 August 2021
Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine. View Full-Text
Keywords: central nervous system (CNS); ependymal cells; neural stem and progenitor cells (NSPC); NG2+ cells; neurodegenerative diseases; regenerative medicine; retina injury; spinal cord injury (SCI); traumatic brain injury (TBI) central nervous system (CNS); ependymal cells; neural stem and progenitor cells (NSPC); NG2+ cells; neurodegenerative diseases; regenerative medicine; retina injury; spinal cord injury (SCI); traumatic brain injury (TBI)
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MDPI and ACS Style

Finkel, Z.; Esteban, F.; Rodriguez, B.; Fu, T.; Ai, X.; Cai, L. Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease. Cells 2021, 10, 2045. https://doi.org/10.3390/cells10082045

AMA Style

Finkel Z, Esteban F, Rodriguez B, Fu T, Ai X, Cai L. Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease. Cells. 2021; 10(8):2045. https://doi.org/10.3390/cells10082045

Chicago/Turabian Style

Finkel, Zachary, Fatima Esteban, Brianna Rodriguez, Tianyue Fu, Xin Ai, and Li Cai. 2021. "Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease" Cells 10, no. 8: 2045. https://doi.org/10.3390/cells10082045

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