Next Article in Journal
Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus
Next Article in Special Issue
Interpretable Autoencoders Trained on Single Cell Sequencing Data Can Transfer Directly to Data from Unseen Tissues
Previous Article in Journal
Transcriptional Profiles of Cell Fate Transitions Reveal Early Drivers of Neuronal Apoptosis and Survival
Previous Article in Special Issue
Comparative Analyses of Single-Cell Transcriptomic Profiles between In Vitro Totipotent Blastomere-like Cells and In Vivo Early Mouse Embryonic Cells
Article

Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers

Cellular, Molecular and Developmental Neurobiology Department, Instituto Cajal-CSIC, 8002 Madrid, Spain
*
Author to whom correspondence should be addressed.
Ph.D. Program in Neuroscience, UAM, 28049 Madrid, Spain.
Academic Editors: Tuhin Subhra Santra, Fan-Gang Tseng and Hakan Aldskogius
Cells 2021, 10(11), 3237; https://doi.org/10.3390/cells10113237
Received: 18 August 2021 / Revised: 15 November 2021 / Accepted: 18 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Single Cell Analysis 2.0)
During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons, astrocytes, oligodendrocytes, and NG2-glia in the cerebral cortex. However, the potential of individual progenitors to form glial lineages remains poorly understood. To further investigate the cell progeny of single pallial GFAP-expressing progenitors, we used the in vivo genetic lineage-tracing method, the UbC-(GFAP-PB)-StarTrack. After targeting those progenitors in embryonic mice brains, we tracked their adult glial progeny in lower cortical layers. Clonal analyses revealed the presence of clones containing sibling cells of either a glial cell type (uniform clones) or two different glial cell types (mixed clones). Further, the clonal size and rostro-caudal cell dispersion of sibling cells differed depending on the cell type. We concluded that pallial E14 neural progenitors are a heterogeneous cell population with respect to which glial cell type they produce, as well as the clonal size of their cell progeny. View Full-Text
Keywords: StarTrack; glial cell types; lineage; progenitor; astrocytes; oligodendroglia; NG2-glia; clonal analysis; cortex; mice StarTrack; glial cell types; lineage; progenitor; astrocytes; oligodendroglia; NG2-glia; clonal analysis; cortex; mice
Show Figures

Figure 1

MDPI and ACS Style

Ojalvo-Sanz, A.C.; López-Mascaraque, L. Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers. Cells 2021, 10, 3237. https://doi.org/10.3390/cells10113237

AMA Style

Ojalvo-Sanz AC, López-Mascaraque L. Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers. Cells. 2021; 10(11):3237. https://doi.org/10.3390/cells10113237

Chicago/Turabian Style

Ojalvo-Sanz, Ana C., and Laura López-Mascaraque. 2021. "Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers" Cells 10, no. 11: 3237. https://doi.org/10.3390/cells10113237

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop