Next Article in Journal
Iron Metabolism in Pancreatic Beta-Cell Function and Dysfunction
Previous Article in Journal
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
Previous Article in Special Issue
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells
Review

Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease

Feinberg Cardiovascular and Renal Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Academic Editor: Wayne Carver
Cells 2021, 10(11), 2839; https://doi.org/10.3390/cells10112839
Received: 29 August 2021 / Revised: 15 October 2021 / Accepted: 18 October 2021 / Published: 22 October 2021
Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of exercise, drug addiction, cigarette smoke, alcoholism, and exposure to environmental pollutants like particulate matter (PM)-induced stresses contribute profoundly to accelerated and chronological cardiovascular aging and associated life threatening diseases. All these stressors alter gene expression epigenetically either through activation or repression of gene transcription via alteration of chromatin remodeling enzymes and chromatin landscape by DNA methylation or histone methylation or histone acetylation. Acetyltransferase p300, a major epigenetic writer of acetylation on histones and transcription factors, contributes significantly to modifications of chromatin landscape of genes involved in cellular aging and cardiovascular diseases. In this review, the key findings those implicate acetyltransferase p300 as a major contributor to cellular senescence or aging related cardiovascular pathologies including vascular dysfunction, cardiac hypertrophy, myocardial infarction, cardiac fibrosis, systolic/diastolic dysfunction, and aortic valve calcification are discussed. The efficacy of natural or synthetic small molecule inhibitor targeting acetyltransferase p300 in amelioration of stress-induced dysregulated gene expression, cellular aging, and cardiovascular disease in preclinical study is also discussed. View Full-Text
Keywords: acetyltransferase p300; small molecule inhibitors; cellular senescence; diabetes; TGF-β; vascular calcification; hypertension; heart disease acetyltransferase p300; small molecule inhibitors; cellular senescence; diabetes; TGF-β; vascular calcification; hypertension; heart disease
Show Figures

Figure 1

MDPI and ACS Style

Ghosh, A.K. Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease. Cells 2021, 10, 2839. https://doi.org/10.3390/cells10112839

AMA Style

Ghosh AK. Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease. Cells. 2021; 10(11):2839. https://doi.org/10.3390/cells10112839

Chicago/Turabian Style

Ghosh, Asish K. 2021. "Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease" Cells 10, no. 11: 2839. https://doi.org/10.3390/cells10112839

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop