Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols
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Tecnun School of Engineering, University of Navarra, Manuel Lardizabal 13, 20018 San Sebastian, Spain
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Biomedical Engineering Centre, University of Navarra, Campus Universitario, 31080 Pamplona, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Andreea-Teodora Iacob
Polymers 2022, 14(7), 1311; https://doi.org/10.3390/polym14071311
Received: 23 February 2022
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Revised: 18 March 2022
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Accepted: 21 March 2022
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Published: 24 March 2022
(This article belongs to the Special Issue Applications of Electrospun Nanofibers)
The electrospinning of hybrid polymers is a versatile fabrication technique which takes advantage of the biological properties of natural polymers and the mechanical properties of synthetic polymers. However, the literature is scarce when it comes to comparisons of blends regarding coatings and the improvements offered thereby in terms of cellular performance. To address this, in the present study, nanofibrous electrospun scaffolds of polycaprolactone (PCL), their coating and their blend with gelatin were compared. The morphology of nanofibrous scaffolds was analyzed under field emission scanning electron microscopy (FE-SEM), indicating the influence of the presence of gelatin. The scaffolds were mechanically tested with tensile tests; PCL and PCL gelatin coated scaffolds showed higher elastic moduli than PCL/gelatin meshes. Viability of mouse embryonic fibroblasts (MEF) was evaluated by MTT assay, and cell proliferation on the scaffold was confirmed by fluorescence staining. The positive results of the MTT assay and cell growth indicated that the scaffolds of PCL/gelatin excelled in comparison to other scaffolds, and may serve as good candidates for tissue engineering applications.
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Keywords:
electrospinning; scaffold; PCL; gelatin; tissue engineering; mechanical properties; characterization
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MDPI and ACS Style
Bikuna-Izagirre, M.; Aldazabal, J.; Paredes, J. Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols. Polymers 2022, 14, 1311. https://doi.org/10.3390/polym14071311
AMA Style
Bikuna-Izagirre M, Aldazabal J, Paredes J. Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols. Polymers. 2022; 14(7):1311. https://doi.org/10.3390/polym14071311
Chicago/Turabian StyleBikuna-Izagirre, Maria, Javier Aldazabal, and Jacobo Paredes. 2022. "Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols" Polymers 14, no. 7: 1311. https://doi.org/10.3390/polym14071311
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