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Article

Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents

1
RECETOX, Faculty of Science, Masaryk University, Kamenice 3, CZ-62500 Brno, Czech Republic
2
Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
3
Department of Experimental Phycology and Ecotoxicology, Institute of Botany of the CAS, CZ-60200 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Loris Pietrelli
Polymers 2021, 13(7), 1025; https://doi.org/10.3390/polym13071025
Received: 5 March 2021 / Revised: 20 March 2021 / Accepted: 23 March 2021 / Published: 26 March 2021
(This article belongs to the Special Issue Polymers Materials for Water Treatment)
Extensive, uncontrolled growth of algae and cyanobacteria is an environmental, public health, economic, and technical issue in managing natural and engineered water systems. Synthetic biomimetic polymers have been almost exclusively considered antimicrobial alternatives to conventional antibiotics to treat human bacterial infections. Very little is known about their applicability in an aquatic environment. Here, we introduce synthetic biomimetic polymethacrylates (SBPs) as a cost-effective and chemically facile, flexible platform for designing a new type of agent suitable for controlling and mitigating photosynthetic microorganisms. Since SBPs are cationic and membranolytic in heterotrophic bacteria, we hypothesized they could also interact with negatively charged cyanobacterial or algal cell walls and membranes. We demonstrated that SBPs inhibited the growth of aquatic photosynthetic organisms of concern, i.e., cyanobacteria (Microcystis aeruginosa and Synechococcus elongatus) and green algae (Chlamydomonas reinhardtii and Desmodesmus quadricauda), with 50% effective growth-inhibiting concentrations ranging between 95 nM and 6.5 μM. Additionally, SBPs exhibited algicidal effects on C. reinhardtii and cyanocidal effects on picocyanobacterium S. elongatus and microcystin-producing cyanobacterium M. aeruginosa. SBP copolymers, particularly those with moderate hydrophobic content, induced more potent cyanostatic and cyanocidal effects than homopolymers. Thus, biomimetic polymers are a promising platform for the design of anti-cyanobacterial and anti-algal agents for water treatment. View Full-Text
Keywords: algae; antimicrobials; biomimetic polymers; cyanobacteria; polymethacrylates; water treatment algae; antimicrobials; biomimetic polymers; cyanobacteria; polymethacrylates; water treatment
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MDPI and ACS Style

Mikula, P.; Mlnaříková, M.; Nadres, E.T.; Takahashi, H.; Babica, P.; Kuroda, K.; Bláha, L.; Sovadinová, I. Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents. Polymers 2021, 13, 1025. https://doi.org/10.3390/polym13071025

AMA Style

Mikula P, Mlnaříková M, Nadres ET, Takahashi H, Babica P, Kuroda K, Bláha L, Sovadinová I. Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents. Polymers. 2021; 13(7):1025. https://doi.org/10.3390/polym13071025

Chicago/Turabian Style

Mikula, Přemysl, Marie Mlnaříková, Enrico T. Nadres, Haruko Takahashi, Pavel Babica, Kenichi Kuroda, Luděk Bláha, and Iva Sovadinová. 2021. "Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents" Polymers 13, no. 7: 1025. https://doi.org/10.3390/polym13071025

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