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Review

Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review

1
Department of Chemistry, Bar-Ilan Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel
2
Department of Civil and Environmental Engineering, Ben-Gurion University of the Negev, Be’er Sheva 84105, Israel
3
Department of Chemistry, Nuclear Research Center-Negev, Be’er Sheva 84190, Israel
*
Authors to whom correspondence should be addressed.
Academic Editors: M. Ali Aboudzadeh and Shaghayegh Hamzehlou
Polymers 2021, 13(24), 4307; https://doi.org/10.3390/polym13244307
Received: 21 November 2021 / Revised: 29 November 2021 / Accepted: 6 December 2021 / Published: 9 December 2021
(This article belongs to the Special Issue Function of Polymers in Encapsulation Process)
Natural polymers, such as polysaccharides and polypeptides, are potential candidates to serve as carriers of biomedical cargo. Natural polymer-based carriers, having a core–shell structural configuration, offer ample scope for introducing multifunctional capabilities and enable the simultaneous encapsulation of cargo materials of different physical and chemical properties for their targeted delivery and sustained and stimuli-responsive release. On the other hand, carriers with a porous matrix structure offer larger surface area and lower density, in order to serve as potential platforms for cell culture and tissue regeneration. This review explores the designing of micro- and nano-metric core–shell capsules and porous spheres, based on various functions. Synthesis approaches, mechanisms of formation, general- and function-specific characteristics, challenges, and future perspectives are discussed. Recent advances in protein-based carriers with a porous matrix structure and different core–shell configurations are also presented in detail. View Full-Text
Keywords: natural polymers; polymeric capsules; porous polymeric spheres; active pharmaceutical carriers; drug delivery; stimuli-responsive release; cell culture platforms natural polymers; polymeric capsules; porous polymeric spheres; active pharmaceutical carriers; drug delivery; stimuli-responsive release; cell culture platforms
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MDPI and ACS Style

Sharma, K.; Porat, Z.; Gedanken, A. Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review. Polymers 2021, 13, 4307. https://doi.org/10.3390/polym13244307

AMA Style

Sharma K, Porat Z, Gedanken A. Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review. Polymers. 2021; 13(24):4307. https://doi.org/10.3390/polym13244307

Chicago/Turabian Style

Sharma, Kusha, Ze’ev Porat, and Aharon Gedanken. 2021. "Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review" Polymers 13, no. 24: 4307. https://doi.org/10.3390/polym13244307

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