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Open AccessArticle

β-Cyclodextrin–Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells

1
Institute of Environmental Science, Department of Chemistry, Shanxi University, Taiyuan 030006, China
2
Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China
3
State Key Laboratory of Biotherapy, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(1), 133; https://doi.org/10.3390/polym11010133
Received: 7 December 2018 / Revised: 29 December 2018 / Accepted: 8 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Magnetic Field in Polymer Research)
A multifunctional targeted drug delivery platform (CDHA–MGO) has been successfully constructed by grafting β-cyclodextrin–hyaluronic acid polymers (CDHA) to Fe3O4–graphene oxide (MGO). The obtained CDHA–MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g−1. Meanwhile, the Fe3O4–graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite ([email protected]–MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy. View Full-Text
Keywords: β-cyclodextrin; hyaluronic acid; magnetic graphene oxide; near-infrared; photo-chemotherapy β-cyclodextrin; hyaluronic acid; magnetic graphene oxide; near-infrared; photo-chemotherapy
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MDPI and ACS Style

Liang, W.; Huang, Y.; Lu, D.; Ma, X.; Gong, T.; Cui, X.; Yu, B.; Yang, C.; Dong, C.; Shuang, S. β-Cyclodextrin–Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells. Polymers 2019, 11, 133.

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