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Open AccessArticle

Investigation and Characterization of Plasma-Treated Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Biopolymers for an In Vitro Cellular Study of Mouse Adipose-Derived Stem Cells

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Biorefinery and Bioprocess Engineering Laboratory, Department of Chemical Engineering and Materials Science, Yuan Ze University, No. 135, Yuan-Tung Road, Chungli, Taoyuan 320, Taiwan
2
Graduate Institute of Biomedical Engineering, National Chung Hsing University, No. 145, Xing-Da Road, South District, Taichung 402, Taiwan
*
Author to whom correspondence should be addressed.
Polymers 2018, 10(4), 355; https://doi.org/10.3390/polym10040355
Received: 5 February 2018 / Revised: 13 March 2018 / Accepted: 20 March 2018 / Published: 22 March 2018
(This article belongs to the Special Issue Biodegradable and Biobased Polyesters)
Polyhydroxyalkanoates (PHAs) are a type of thermoprocessable and biodegradable polyester, which represent a potential sustainable replacement for fossil-fuel synthetic polymers, such as polypropylene and polyethylene. In recent years, copolymers of PHAs, i.e., poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), have received attention for medical and packaging industrial applications, due to their biodegradable, toxic-free, and biocompatible nature. This study investigated and characterized plasma-treated PHB and PHBV films fermented with Ralstonia eutropha H16. The X-ray photoelectron spectroscopy (XPS) and water contact angle analyses on the plasma-treated PHB and PHBV film surfaces revealed an increase in the number of functional groups and contact angle degree, respectively, compared to that of the untreated films. In addition, an in vitro experiment of mouse adipose-derived stem cells showed better growth and adhesion of the cells on the surface of plasma-treated PHBV film. Overall, these results reveal that plasma surface modifications are useful in biomaterial development. View Full-Text
Keywords: biocompatibility; biopolymers; hydrophilicity; hydrophobicity; in vitro cellular study; plasma surface modification; poly(3-hydroxybutyrate); poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biocompatibility; biopolymers; hydrophilicity; hydrophobicity; in vitro cellular study; plasma surface modification; poly(3-hydroxybutyrate); poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
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MDPI and ACS Style

Chang, C.-K.; Wang, H.-M.D.; Lan, J.C.-W. Investigation and Characterization of Plasma-Treated Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Biopolymers for an In Vitro Cellular Study of Mouse Adipose-Derived Stem Cells. Polymers 2018, 10, 355.

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