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Catalysts 2019, 9(3), 300; https://doi.org/10.3390/catal9030300

Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors

1
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
2
Osaka Municipal Technical Research Institute, Electronic Material Research Division, 1-6-50, Morinomiya, Joto-ku, Osaka 536-8553, Japan
3
Emaus Kyoto Inc. R&D, 26 Nishida-cho, Saiin, Ukyo-ku, Kyoto 615-0055, Japan
4
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan
*
Authors to whom correspondence should be addressed.
Received: 2 March 2019 / Revised: 14 March 2019 / Accepted: 19 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Catalysts for Suzuki–Miyaura Coupling Reaction)
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Abstract

The space integration of the lithiation of aryl halides, the borylation of aryllithiums, and Suzuki–Miyaura coupling using a Pd catalyst supported by a polymer monolith flow reactor without using an intentionally added base was achieved. To scale up the process, a series connection of the monolith Pd reactor was examined. To suppress the increase in the pressure drop caused by the series connection, a monolith reactor having larger pore sizes was developed by varying the temperature of the monolith preparation. The monolithic Pd reactor having larger pore sizes enabled Suzuki–Miyaura coupling at a higher flow rate because of a lower pressure drop and, therefore, an increase in productivity. The present study indicates that series connection of the reactors with a higher flow rate serves as a good method for increasing the productivity without decreasing the yields. View Full-Text
Keywords: flow synthesis; monolith reactors flow synthesis; monolith reactors
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Nagaki, A.; Hirose, K.; Moriwaki, Y.; Takumi, M.; Takahashi, Y.; Mitamura, K.; Matsukawa, K.; Ishizuka, N.; Yoshida, J.-I. Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors. Catalysts 2019, 9, 300.

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