Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors
AbstractThe space integration of the lithiation of aryl halides, the borylation of aryllithiums, and Suzuki–Miyaura coupling using a Pd catalyst supported by a polymer monolith flow reactor without using an intentionally added base was achieved. To scale up the process, a series connection of the monolith Pd reactor was examined. To suppress the increase in the pressure drop caused by the series connection, a monolith reactor having larger pore sizes was developed by varying the temperature of the monolith preparation. The monolithic Pd reactor having larger pore sizes enabled Suzuki–Miyaura coupling at a higher flow rate because of a lower pressure drop and, therefore, an increase in productivity. The present study indicates that series connection of the reactors with a higher flow rate serves as a good method for increasing the productivity without decreasing the yields. View Full-Text
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Nagaki, A.; Hirose, K.; Moriwaki, Y.; Takumi, M.; Takahashi, Y.; Mitamura, K.; Matsukawa, K.; Ishizuka, N.; Yoshida, J.-I. Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors. Catalysts 2019, 9, 300.
Nagaki A, Hirose K, Moriwaki Y, Takumi M, Takahashi Y, Mitamura K, Matsukawa K, Ishizuka N, Yoshida J-I. Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors. Catalysts. 2019; 9(3):300.Chicago/Turabian Style
Nagaki, Aiichiro; Hirose, Katsuyuki; Moriwaki, Yuya; Takumi, Masahiro; Takahashi, Yusuke; Mitamura, Koji; Matsukawa, Kimihiro; Ishizuka, Norio; Yoshida, Jun-ichi. 2019. "Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors." Catalysts 9, no. 3: 300.
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