Next Article in Journal
Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones
Next Article in Special Issue
Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors
Previous Article in Journal
One-Step Synthesis of MoS2/TiSi2 via an In Situ Photo-Assisted Reduction Method for Enhanced Photocatalytic H2 Evolution under Simulated Sunlight Illumination
Previous Article in Special Issue
Recent Developments in the Suzuki–Miyaura Reaction Using Nitroarenes as Electrophilic Coupling Reagents
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle

Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
Osaka Municipal Technical Research Institute, Electronic Material Research Division, 1-6-50, Morinomiya, Joto-ku, Osaka 536-8553, Japan
Emaus Kyoto Inc. R&D, 26 Nishida-cho, Saiin, Ukyo-ku, Kyoto 615-0055, Japan
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan
Authors to whom correspondence should be addressed.
Catalysts 2019, 9(3), 300;
Received: 2 March 2019 / Revised: 14 March 2019 / Accepted: 19 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Catalysts for Suzuki–Miyaura Coupling Reaction)
PDF [12799 KB, uploaded 25 March 2019]
  |     |  


The space integration of the lithiation of aryl halides, the borylation of aryllithiums, and Suzuki–Miyaura coupling using a Pd catalyst supported by a polymer monolith flow reactor without using an intentionally added base was achieved. To scale up the process, a series connection of the monolith Pd reactor was examined. To suppress the increase in the pressure drop caused by the series connection, a monolith reactor having larger pore sizes was developed by varying the temperature of the monolith preparation. The monolithic Pd reactor having larger pore sizes enabled Suzuki–Miyaura coupling at a higher flow rate because of a lower pressure drop and, therefore, an increase in productivity. The present study indicates that series connection of the reactors with a higher flow rate serves as a good method for increasing the productivity without decreasing the yields. View Full-Text
Keywords: flow synthesis; monolith reactors flow synthesis; monolith reactors

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Nagaki, A.; Hirose, K.; Moriwaki, Y.; Takumi, M.; Takahashi, Y.; Mitamura, K.; Matsukawa, K.; Ishizuka, N.; Yoshida, J.-I. Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors. Catalysts 2019, 9, 300.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Catalysts EISSN 2073-4344 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top