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Article

Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst

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Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Università della Calabria, 87036 Rende (CS), Italy
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Instituto de Biocomputacion y Fisica de Sistemas Complejos (BIFI), Universidad de Zaragoza, Campus San Francisco, 50009 Zaragoza, Aragon, Spain
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Dipartimento di Agraria, Università Telematica San Raffaele, Via di Val Cannuta, 247, 00166 Roma, Italy
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Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, 87036 Rende (CS), Italy
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Authors to whom correspondence should be addressed.
Catalysts 2018, 8(9), 364; https://doi.org/10.3390/catal8090364
Received: 31 July 2018 / Revised: 23 August 2018 / Accepted: 24 August 2018 / Published: 29 August 2018
An efficient, eco-compatible, and very cheap method for the construction of triazoles via eliminative azide–olefin cycloaddition (EAOC) reaction has been developed by a catalytic system, IL/FeCl3, offering a highly regioselective approach to structurally diverse 1,5-disubstituted 1,2,3-triazoles in up to 95% yield. This strategy features the reuse of a catalytic system through simple operations. Mechanistic studies indicated that an asynchronous concerted dipolar cycloaddition–elimination process might be involved. View Full-Text
Keywords: azides; [3 + 2] cycloaddition; EAOC reaction; electron-deficient olefins; 1,2,3-triazoles azides; [3 + 2] cycloaddition; EAOC reaction; electron-deficient olefins; 1,2,3-triazoles
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MDPI and ACS Style

De Nino, A.; Merino, P.; Algieri, V.; Nardi, M.; Di Gioia, M.L.; Russo, B.; Tallarida, M.A.; Maiuolo, L. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst. Catalysts 2018, 8, 364. https://doi.org/10.3390/catal8090364

AMA Style

De Nino A, Merino P, Algieri V, Nardi M, Di Gioia ML, Russo B, Tallarida MA, Maiuolo L. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst. Catalysts. 2018; 8(9):364. https://doi.org/10.3390/catal8090364

Chicago/Turabian Style

De Nino, Antonio, Pedro Merino, Vincenzo Algieri, Monica Nardi, Maria L. Di Gioia, Beatrice Russo, Matteo A. Tallarida, and Loredana Maiuolo. 2018. "Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst" Catalysts 8, no. 9: 364. https://doi.org/10.3390/catal8090364

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