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Catalysts 2018, 8(9), 364; https://doi.org/10.3390/catal8090364

Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst

1
Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Università della Calabria, 87036 Rende (CS), Italy
2
Instituto de Biocomputacion y Fisica de Sistemas Complejos (BIFI), Universidad de Zaragoza, Campus San Francisco, 50009 Zaragoza, Aragon, Spain
3
Dipartimento di Agraria, Università Telematica San Raffaele, Via di Val Cannuta, 247, 00166 Roma, Italy
4
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, 87036 Rende (CS), Italy
*
Authors to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 23 August 2018 / Accepted: 24 August 2018 / Published: 29 August 2018
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Abstract

An efficient, eco-compatible, and very cheap method for the construction of triazoles via eliminative azide–olefin cycloaddition (EAOC) reaction has been developed by a catalytic system, IL/FeCl3, offering a highly regioselective approach to structurally diverse 1,5-disubstituted 1,2,3-triazoles in up to 95% yield. This strategy features the reuse of a catalytic system through simple operations. Mechanistic studies indicated that an asynchronous concerted dipolar cycloaddition–elimination process might be involved. View Full-Text
Keywords: azides; [3 + 2] cycloaddition; EAOC reaction; electron-deficient olefins; 1,2,3-triazoles azides; [3 + 2] cycloaddition; EAOC reaction; electron-deficient olefins; 1,2,3-triazoles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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De Nino, A.; Merino, P.; Algieri, V.; Nardi, M.; Di Gioia, M.L.; Russo, B.; Tallarida, M.A.; Maiuolo, L. Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as an Efficient and Reusable Homogeneous Catalyst. Catalysts 2018, 8, 364.

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