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Chitosan Aerogel Catalyzed Asymmetric Aldol Reaction in Water: Highly Enantioselective Construction of 3-Substituted-3-hydroxy-2-oxindoles

1,2, 2, 1,* and 2,*
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
Authors to whom correspondence should be addressed.
Academic Editor: Luca Gonsalvi
Catalysts 2016, 6(12), 186;
Received: 3 October 2016 / Revised: 10 November 2016 / Accepted: 21 November 2016 / Published: 28 November 2016
(This article belongs to the Special Issue Homogeneous Catalysis and Mechanisms in Water and Biphasic Media)
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A chitosan aerogel catalyzed asymmetric aldol reaction of ketones with isatins in the presence of water is described. This protocol was found to be environmentally benign, because it proceeds smoothly in water and the corresponding aldol products were obtained in excellent yields with good enantioselectivities. View Full-Text
Keywords: chitosan aerogel; aldol reaction; water; isatin chitosan aerogel; aldol reaction; water; isatin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dong, H.; Liu, J.; Ma, L.; Ouyang, L. Chitosan Aerogel Catalyzed Asymmetric Aldol Reaction in Water: Highly Enantioselective Construction of 3-Substituted-3-hydroxy-2-oxindoles. Catalysts 2016, 6, 186.

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