Next Article in Journal
Met in Urological Cancers
Next Article in Special Issue
Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion
Previous Article in Journal
Analysis of Intensity-Modulated Radiation Therapy (IMRT), Proton and 3D Conformal Radiotherapy (3D-CRT) for Reducing Perioperative Cardiopulmonary Complications in Esophageal Cancer Patients
Article Menu

Export Article

Open AccessReview
Cancers 2014, 6(4), 2369-2386;

Dynamic Changes in Numbers and Properties of Circulating Tumor Cells and Their Potential Applications

Institute of Microbiology and Immunology, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan
Department of Education and Research, Taipei City Hospital, Taipei 10629, Taiwan
Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, Taipei 11529, Taiwan
Biomedical Imaging Research Center, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
National PET/Cyclotron Center, Taipei Veterans General Hospital, Taipei, 11217, Taiwan
Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan
VGH Yang-Ming Genome Research Center, Taipei 11221, Taiwan
Authors to whom correspondence should be addressed.
Received: 29 September 2014 / Revised: 25 November 2014 / Accepted: 8 December 2014 / Published: 16 December 2014
(This article belongs to the Special Issue Cancer Cell Invasion)
Full-Text   |   PDF [804 KB, uploaded 16 December 2014]   |  


Circulating tumor cells (CTCs) can be detected in the blood of different types of early or advanced cancer using immunology-based assays or nucleic acid methods. The detection and quantification of CTCs has significant clinical utility in the prognosis of metastatic breast, prostate, and colorectal cancers. CTCs are a heterogeneous population of cells and often different from those of their respective primary tumor. Understanding the biology of CTCs may provide useful predictive information for the selection of the most appropriate treatment. Therefore, CTC detection and characterization could become a valuable tool to refine prognosis and serve as a “real-time biopsy” and has the potential to guide precision cancer therapies, monitor cancer treatment, and investigate the process of metastasis. View Full-Text
Keywords: circulating tumor cells; metastasis; CTC enrichment and enumeration circulating tumor cells; metastasis; CTC enrichment and enumeration

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tseng, J.-Y.; Yang, C.-Y.; Liang, S.-C.; Liu, R.-S.; Jiang, J.-K.; Lin, C.-H. Dynamic Changes in Numbers and Properties of Circulating Tumor Cells and Their Potential Applications. Cancers 2014, 6, 2369-2386.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top