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Cancers 2013, 5(4), 1426-1438; doi:10.3390/cancers5041426
Review

The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer

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Received: 2 September 2013 / Revised: 18 September 2013 / Accepted: 30 September 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Vitamin D: Role in Cancer Causation, Progression and Therapy)
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Abstract

Although the epidemiologic evidence that adequate vitamin D nutrition protects against non-melanoma skin cancer (NMSC) is limited, recent evidence that the vitamin D receptor (VDR) is protective is compelling. The role of vitamin D signaling in limiting the proliferation while promoting the differentiation of keratinocytes, the major cell in the epidermis from which NMSC are derived, is well known. However, recent findings that mice lacking the VDR are predisposed to skin cancer has brought to the fore the question of how the VDR is protective. In this review we will look first at the role of vitamin D signaling in regulating the proliferation and differentiation of keratinocytes. We will examine two pathways, β-catenin (CTNNB) and hedgehog (HH), that are regulated by vitamin D signaling and may contribute to the dysregulated proliferation and differentiation in the absence of VDR. We will then examine the failure of VDR deficient keratinocytes to repair DNA damaged by UVB. Finally we will examine the change in long non-coding RNA (LncRNA) expression in VDR null keratinocytes that in other cells is associated with malignant transformation, a potential newly appreciated mechanism by which vitamin D signaling is protective against NMSC.
Keywords: vitamin D receptor (VDR); β-catenin (CTNNB); hedgehog (HH); DNA damage repair (DDR); long non coding RNA (LncRNA) vitamin D receptor (VDR); β-catenin (CTNNB); hedgehog (HH); DNA damage repair (DDR); long non coding RNA (LncRNA)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bikle, D.D.; Jiang, Y. The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer. Cancers 2013, 5, 1426-1438.

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