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Cancers 2011, 3(1), 883-896;

Components of Cell-Matrix Linkage as Potential New Markers for Prostate Cancer

Center for Molecular Medicine, Deptartment Vascular Matrix Biology, Excellence Cluster Cardio-Pulmonary System, Frankfurt University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
Author to whom correspondence should be addressed.
Received: 25 January 2011 / Revised: 12 February 2011 / Accepted: 17 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Organ-Specific Metastasis Formation)
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Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment. However, about 20% of diagnosed prostate cancers tend to metastasize and require treatment. Existing diagnostic methods may fail to accurately recognize the transition of a dormant, non-aggressive tumor into highly malignant prostate cancer. Therefore, new diagnostic tools are needed to improve diagnosis and therapy of prostate carcinoma. This review evaluates existing methods to diagnose prostate carcinoma, such as the biochemical marker prostate-specific antigen (PSA), but also discusses the possibility to use the altered expression of integrins and laminin-332 in prostate carcinomas as diagnostic tools and therapeutic targets of prostate cancer. View Full-Text
Keywords: prostate cancer; laminins; integrins; proteases; diagnosis prostate cancer; laminins; integrins; proteases; diagnosis

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Navdaev, A.; Eble, J.A. Components of Cell-Matrix Linkage as Potential New Markers for Prostate Cancer. Cancers 2011, 3, 883-896.

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