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The Role of Apoptosis in the Pathology of Pancreatic Cancer

Department of Visceral-, Thoracic- and Vascular-Surgery, University Hospital Dresden, Dresden, Germany
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Cancers 2011, 3(1), 1-16; https://doi.org/10.3390/cancers3010001
Received: 11 November 2010 / Revised: 14 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
(This article belongs to the Special Issue Pancreatic Cancer)
Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer. View Full-Text
Keywords: apoptosis; signal transduction pathway; pancreatic cancer apoptosis; signal transduction pathway; pancreatic cancer
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Samm, N.; Werner, K.; Rückert, F.; Saeger, H.D.; Grützmann, R.; Pilarsky, C. The Role of Apoptosis in the Pathology of Pancreatic Cancer. Cancers 2011, 3, 1-16.

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