Review Reports
- Linda Galasso1,†,
- Lucia Cerrito1,2,† and
- Valeria Maccauro1
- et al.
Reviewer 1: Anonymous Reviewer 2: Chih-Che Lin Reviewer 3: Anonymous
Round 1
Reviewer 1 Report
Comments and Suggestions for Authors
The manuscript entitled " HCC and the multifaceted relationship with its microenvironment: attacking HCC defensive fortress. " was reviewed.
This paper is well organized. What is the authors' main focus in HCC? The authors' approach should be included.
Comments on the Quality of English Languagenone
Author Response
ANSWER TO REVIEWER 1: Dear Doctors, we would like to thank you for your observations; we would like to underline that our paper is focalized on the microenvironment of hepatocellular carcinoma and on the possible implications that this really complex system could have in the context of tumor treatment (page 2, line 74-78).
Reviewer 2 Report
Comments and Suggestions for AuthorsThe paper is well written.
Treatment modalities such as surgical resection, radiofrequency ablation, and 66 transarterial chemoembolization are effective for liver-located HCC.（line 67-68).
The statement could be more comprehensive such as transplant and radiotherpay.
Author Response
ANSWER TO REVIEWER 2: We are grateful for your kind attention and suggestions. As per your advice, we added “transplantation and radiotherapy“ to HCC treatments (page 2, line 66-67).
Reviewer 3 Report
Comments and Suggestions for AuthorsThis is a well-written review that described in details the cellular interactions between HCC and its microenvironment.
There is an issue with tables 1 and 2.
Author Response
ANSWER TO REVIEWER 3: Dear Doctors, we corrected the issue about the second table and we added it to our paper (pages 15-16).