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Harnessing NK Cell Checkpoint-Modulating Immunotherapies

Institute of cellular therapeutics, Hannover Medical School, 30625 Hannover, Germany
Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany
Institute of Clinical Immunology, University of Leipzig, 04103 Leipzig, Germany
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1807;
Received: 31 May 2020 / Revised: 30 June 2020 / Accepted: 2 July 2020 / Published: 6 July 2020
(This article belongs to the Special Issue Antigens and Cancer Therapy)
During the host immune response, the precise balance of the immune system, regulated by immune checkpoint, is required to avoid infection and cancer. These immune checkpoints are the mainstream regulator of the immune response and are crucial for self-tolerance. During the last decade, various new immune checkpoint molecules have been studied, providing an attractive path to evaluate their potential role as targets for effective therapeutic interventions. Checkpoint inhibitors have mainly been explored in T cells until now, but natural killer (NK) cells are a newly emerging target for the determination of checkpoint molecules. Simultaneously, an increasing number of therapeutic dimensions have been explored, including modulatory and inhibitory checkpoint molecules, either causing dysfunction or promoting effector functions. Furthermore, the combination of the immune checkpoint with other NK cell-based therapeutic strategies could also strengthen its efficacy as an antitumor therapy. In this review, we have undertaken a comprehensive review of the literature to date regarding underlying mechanisms of modulatory and inhibitory checkpoint molecules. View Full-Text
Keywords: Natural killer cell (NK); cancer immunotherapy (CI); immune checkpoint costimulatory; immune therapeutics; modulatory immune checkpoint; inhibitory immune checkpoint Natural killer cell (NK); cancer immunotherapy (CI); immune checkpoint costimulatory; immune therapeutics; modulatory immune checkpoint; inhibitory immune checkpoint
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MDPI and ACS Style

Chauhan, S.K.S.; Koehl, U.; Kloess, S. Harnessing NK Cell Checkpoint-Modulating Immunotherapies. Cancers 2020, 12, 1807.

AMA Style

Chauhan SKS, Koehl U, Kloess S. Harnessing NK Cell Checkpoint-Modulating Immunotherapies. Cancers. 2020; 12(7):1807.

Chicago/Turabian Style

Chauhan, Sachin K.S.; Koehl, Ulrike; Kloess, Stephan. 2020. "Harnessing NK Cell Checkpoint-Modulating Immunotherapies" Cancers 12, no. 7: 1807.

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