Next Article in Journal
Reactive Oxygen Species in the Tumor Microenvironment: An Overview
Previous Article in Journal
How to Deal with Second Line Dilemma in Metastatic Colorectal Cancer? A Systematic Review and Meta-Analysis
Previous Article in Special Issue
Prognostic Significance of CT-Attenuation of Tumor-Adjacent Breast Adipose Tissue in Breast Cancer Patients with Surgical Resection
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessPerspective

FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: Today, Tomorrow, and Beyond

Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark
Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark
Centre for Innovative Medical Technology, Odense University Hospital, 5000 Odense, Denmark
Department of Nuclear Medicine, Lillebaelt Hospital, 7100 Vejle, Denmark
Department of Oncology, Odense University Hospital, 5000 Odense, Denmark
Department of Clinical Genetics, Odense University Hospital, 5000 Odense, Denmark
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1190; (registering DOI)
Received: 20 July 2019 / Revised: 14 August 2019 / Accepted: 14 August 2019 / Published: 15 August 2019
(This article belongs to the Special Issue Role of Medical Imaging in Cancers)
PDF [9316 KB, uploaded 20 August 2019]
  |     |  


While current international guidelines include imaging of the target lesion for response monitoring in metastatic breast cancer, they do not provide specific recommendations for choice of imaging modality or response criteria. This is important as clinical decisions may vary depending on which imaging modality is used for monitoring metastatic breast cancer. FDG-PET/CT has shown high accuracy in diagnosing metastatic breast cancer, and the Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) have shown higher predictive values than the CT-based Response Evaluation Criteria in Solid Tumors (RECIST) for prediction of progression-free survival. No studies have yet addressed the clinical impact of using different imaging modalities or response evaluation criteria for longitudinal response monitoring in metastatic breast cancer. We present a case study of a patient with metastatic breast cancer who was monitored first with conventional CT and then with FDG-PET/CT. We retrospectively applied PERCIST to evaluate the longitudinal response to treatment. We used the one-lesion PERCIST model measuring SULpeak in the hottest metastatic lesion on consecutive scans. This model provides a continuous variable that allows graphical illustration of disease fluctuation along with response categories. The one-lesion PERCIST approach seems able to reflect molecular changes and has the potential to support clinical decision-making. Prospective clinical studies addressing the clinical impact of PERCIST in metastatic breast cancer are needed to establish evidence-based recommendations for response monitoring in this disease. View Full-Text
Keywords: precision oncology; FDG-PET/CT; PERCIST; metastatic breast cancer precision oncology; FDG-PET/CT; PERCIST; metastatic breast cancer

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hildebrandt, M.G.; Lauridsen, J.F.; Vogsen, M.; Holm, J.; Vilstrup, M.H.; Braad, P.-E.; Gerke, O.; Thomassen, M.; Ewertz, M.; Høilund-Carlsen, P.F.; The Centre for Personalized Response Monitoring in Oncology (PREMIO). FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: Today, Tomorrow, and Beyond. Cancers 2019, 11, 1190.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top