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Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications

1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
3
Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
4
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
5
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 899; https://doi.org/10.3390/cancers11070899
Received: 10 June 2019 / Revised: 25 June 2019 / Accepted: 25 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue Ion Channels in Cancer)
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PDF [1374 KB, uploaded 27 June 2019]
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Abstract

The remodeling of Ca2+ homeostasis has been implicated as a critical event in driving malignant phenotypes, such as tumor cell proliferation, motility, and metastasis. Store-operated Ca2+ entry (SOCE) that is elicited by the depletion of the endoplasmic reticulum (ER) Ca2+ stores constitutes the major Ca2+ influx pathways in most nonexcitable cells. Functional coupling between the plasma membrane Orai channels and ER Ca2+-sensing STIM proteins regulates SOCE activation. Previous studies in the human breast, cervical, and other cancer types have shown the functional significance of STIM/Orai-dependent Ca2+ signals in cancer development and progression. This article reviews the information on the regulatory mechanisms of STIM- and Orai-dependent SOCE pathways in the malignant characteristics of cancer, such as proliferation, resistance, migration, invasion, and metastasis. The recent investigations focusing on the emerging importance of SOCE in the cells of the tumor microenvironment, such as tumor angiogenesis and antitumor immunity, are also reviewed. The clinical implications as cancer therapeutics are discussed. View Full-Text
Keywords: Ca2+ signaling; orai; stromal interaction molecule (STIM); store-operated Ca2+ entry (SOCE); migration Ca2+ signaling; orai; stromal interaction molecule (STIM); store-operated Ca2+ entry (SOCE); migration
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Chen, Y.-F.; Lin, P.-C.; Yeh, Y.-M.; Chen, L.-H.; Shen, M.-R. Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications. Cancers 2019, 11, 899.

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