3D-Printed Chips: Compatibility of Additive Manufacturing Photopolymeric Substrata with Biological Applications

Carve, Megan; Wlodkowic, Donald

doi:10.3390/mi9020091

Volume 9, Issue 2

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3D-Printed Chips: Compatibility of Additive Manufacturing Photopolymeric Substrata with Biological Applications

Megan Carve^1,†

and Donald Wlodkowic^1,2,*,†

School of Science, RMIT University, Melbourne, VIC 3083, Australia

Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, VIC 3083, Australia

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Micromachines 2018, 9(2), 91; https://doi.org/10.3390/mi9020091

Received: 27 January 2018 / Revised: 14 February 2018 / Accepted: 19 February 2018 / Published: 23 February 2018

(This article belongs to the Special Issue 3D Printed Microfluidic Devices)

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Abstract

Additive manufacturing (AM) is ideal for building adaptable, structurally complex, three-dimensional, monolithic lab-on-chip (LOC) devices from only a computer design file. Consequently, it has potential to advance micro- to milllifluidic LOC design, prototyping, and production and further its application in areas of biomedical and biological research. However, its application in these areas has been hampered due to material biocompatibility concerns. In this review, we summarise commonly used AM techniques: vat polymerisation and material jetting. We discuss factors influencing material biocompatibility as well as methods to mitigate material toxicity and thus promote its application in these research fields. View Full-Text

Keywords: lab-on-a-chip; bioassay; toxicity; additive manufacturing; polymers; 3D printing

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Carve, M.; Wlodkowic, D. 3D-Printed Chips: Compatibility of Additive Manufacturing Photopolymeric Substrata with Biological Applications. Micromachines 2018, 9, 91.