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Toxins 2017, 9(10), 316;

Helicobacter pylori Vacuolating Toxin and Gastric Cancer

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA
Author to whom correspondence should be addressed.
Academic Editors: Jean E. Crabtree and Silja Wessler
Received: 13 September 2017 / Revised: 3 October 2017 / Accepted: 5 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue H. pylori Virulence Factors in the Induction of Gastric Cancer)
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Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer. View Full-Text
Keywords: Helicobacter pylori; gastric cancer; pore-forming toxins Helicobacter pylori; gastric cancer; pore-forming toxins

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McClain, M.S.; Beckett, A.C.; Cover, T.L. Helicobacter pylori Vacuolating Toxin and Gastric Cancer. Toxins 2017, 9, 316.

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