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Open AccessArticle

Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice

1
Division of Clinical Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
2
Executive Director of R&D, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Sokcheon Pak
Toxins 2015, 7(8), 2835-2844; https://doi.org/10.3390/toxins7082835
Received: 24 February 2015 / Accepted: 6 July 2015 / Published: 29 July 2015
Amyotrophic lateral sclerosis (ALS) includes progressively degenerated motor neurons in the brainstem, motor cortex, and spinal cord. Recent reports demonstrate the dysfunction of multiple organs, including the lungs, spleen, and liver, in ALS animals and patients. Bee venom acupuncture (BVA) has been used for treating inflammatory diseases in Oriental Medicine. In a previous study, we demonstrated that BV prevented motor neuron death and increased anti-inflammation in the spinal cord of symptomatic hSOD1G93A transgenic mice. In this study, we examined whether BVA’s effects depend on acupuncture point (ST36) in the organs, including the liver, spleen and kidney, of hSOD1G93A transgenic mice. We found that BV treatment at ST36 reduces inflammation in the liver, spleen, and kidney compared with saline-treatment at ST36 and BV injected intraperitoneally in symptomatic hSOD1G93A transgenic mice. Those findings suggest that BV treatment combined with acupuncture stimulation is more effective at reducing inflammation and increasing immune responses compared with only BV treatment, at least in an ALS animal model. View Full-Text
Keywords: amyotrophic lateral sclerosis (ALS); bee venom acupuncture (BVA); anti-inflammation amyotrophic lateral sclerosis (ALS); bee venom acupuncture (BVA); anti-inflammation
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Lee, S.-H.; Choi, S.-M.; Yang, E.J. Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice. Toxins 2015, 7, 2835-2844.

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