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Article

Trichothecene Mycotoxins Inhibit Mitochondrial Translation—Implication for the Mechanism of Toxicity

1
Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA
2
Bacterial Foodborne Pathogens and Mycology Unit, National Center for Agricultural Utilization Research, United States Department of Agriculture, Agricultural Research Service, Peoria, IL 61604, USA
*
Author to whom correspondence should be addressed.
Toxins 2011, 3(12), 1484-1501; https://doi.org/10.3390/toxins3121484
Received: 14 September 2011 / Revised: 18 November 2011 / Accepted: 18 November 2011 / Published: 2 December 2011
(This article belongs to the Special Issue Trichothecenes)
Fusarium head blight (FHB) reduces crop yield and results in contamination of grains with trichothecene mycotoxins. We previously showed that mitochondria play a critical role in the toxicity of a type B trichothecene. Here, we investigated the direct effects of type A and type B trichothecenes on mitochondrial translation and membrane integrity in Saccharomyces cerevisiae. Sensitivity to trichothecenes increased when functional mitochondria were required for growth, and trichothecenes inhibited mitochondrial translation at concentrations, which did not inhibit total translation. In organello translation in isolated mitochondria was inhibited by type A and B trichothecenes, demonstrating that these toxins have a direct effect on mitochondrial translation. In intact yeast cells trichothecenes showed dose-dependent inhibition of mitochondrial membrane potential and reactive oxygen species, but only at doses higher than those affecting mitochondrial translation. These results demonstrate that inhibition of mitochondrial translation is a primary target of trichothecenes and is not secondary to the disruption of mitochondrial membranes. View Full-Text
Keywords: trichothecenes; deoxynivalenol; T-2 toxin; diacetoxyscirpenol; Fusarium; mitochondria; ribosomes; translation; fusion; Fission; ROS trichothecenes; deoxynivalenol; T-2 toxin; diacetoxyscirpenol; Fusarium; mitochondria; ribosomes; translation; fusion; Fission; ROS
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MDPI and ACS Style

Bin-Umer, M.A.; McLaughlin, J.E.; Basu, D.; McCormick, S.; Tumer, N.E. Trichothecene Mycotoxins Inhibit Mitochondrial Translation—Implication for the Mechanism of Toxicity. Toxins 2011, 3, 1484-1501. https://doi.org/10.3390/toxins3121484

AMA Style

Bin-Umer MA, McLaughlin JE, Basu D, McCormick S, Tumer NE. Trichothecene Mycotoxins Inhibit Mitochondrial Translation—Implication for the Mechanism of Toxicity. Toxins. 2011; 3(12):1484-1501. https://doi.org/10.3390/toxins3121484

Chicago/Turabian Style

Bin-Umer, Mohamed Anwar, John E. McLaughlin, Debaleena Basu, Susan McCormick, and Nilgun E. Tumer. 2011. "Trichothecene Mycotoxins Inhibit Mitochondrial Translation—Implication for the Mechanism of Toxicity" Toxins 3, no. 12: 1484-1501. https://doi.org/10.3390/toxins3121484

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