Next Article in Journal
Toxin-Based Therapeutic Approaches
Previous Article in Journal
Biological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom
Previous Article in Special Issue
Genomic Damage in Endstage Renal Disease—Contribution of Uremic Toxins
Open AccessReview

Mechanisms of Cisplatin Nephrotoxicity

Division of Nephrology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Toxins 2010, 2(11), 2490-2518; https://doi.org/10.3390/toxins2112490
Received: 14 September 2010 / Revised: 14 October 2010 / Accepted: 22 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Renal Toxicity)
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention. View Full-Text
Keywords: cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors cisplatin; inflammation; kidney injury; nephrotoxicity; apoptosis; dendritic cells; cytokines; toll-like receptors
Show Figures

Graphical abstract

MDPI and ACS Style

Miller, R.P.; Tadagavadi, R.K.; Ramesh, G.; Reeves, W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2010, 2, 2490-2518.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop