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Review

ADAM-15 Disintegrin-Like Domain Structure and Function

by
Dong Lu
1,2,
Mike Scully
1,
Vijay Kakkar
1 and
Xinjie Lu
1,*
1
Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK
2
Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
*
Author to whom correspondence should be addressed.
Toxins 2010, 2(10), 2411-2427; https://doi.org/10.3390/toxins2102411
Submission received: 30 August 2010 / Revised: 13 October 2010 / Accepted: 18 October 2010 / Published: 19 October 2010
(This article belongs to the Special Issue Disintegrins: Structure-Function and Translational Potential)
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Abstract

The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.
Keywords: ADAM protein; Snake venom toxin; disintegrin; integrin; RGD-motif ADAM protein; Snake venom toxin; disintegrin; integrin; RGD-motif

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MDPI and ACS Style

Lu, D.; Scully, M.; Kakkar, V.; Lu, X. ADAM-15 Disintegrin-Like Domain Structure and Function. Toxins 2010, 2, 2411-2427. https://doi.org/10.3390/toxins2102411

AMA Style

Lu D, Scully M, Kakkar V, Lu X. ADAM-15 Disintegrin-Like Domain Structure and Function. Toxins. 2010; 2(10):2411-2427. https://doi.org/10.3390/toxins2102411

Chicago/Turabian Style

Lu, Dong, Mike Scully, Vijay Kakkar, and Xinjie Lu. 2010. "ADAM-15 Disintegrin-Like Domain Structure and Function" Toxins 2, no. 10: 2411-2427. https://doi.org/10.3390/toxins2102411

APA Style

Lu, D., Scully, M., Kakkar, V., & Lu, X. (2010). ADAM-15 Disintegrin-Like Domain Structure and Function. Toxins, 2(10), 2411-2427. https://doi.org/10.3390/toxins2102411

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