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Article

Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth

1
College of Nursing, University of South Florida, Tampa, FL 33612, USA
2
Department of Anthropology, University of South Florida, Tampa, FL 33620, USA
3
College of Public Health, University of South Florida, Tampa, FL 33612, USA
4
Morsani College of Medicine, Department of Pediatrics, University of South Florida, Tampa, FL 337013, USA
5
College of Nursing, University of Tennessee, Knoxville, TN 37996, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1345; https://doi.org/10.3390/nu12051345
Received: 25 March 2020 / Revised: 29 April 2020 / Accepted: 2 May 2020 / Published: 8 May 2020
(This article belongs to the Special Issue Diet, Gut Microbiota and Metabolic Disorders)
Many very-low-birth-weight (VLBW) infants experience growth faltering in early life despite adequate nutrition. Early growth patterns can affect later neurodevelopmental and anthropometric potentials. The role of the dysbiotic gut microbiome in VLBW infant growth is unknown. Eighty-four VLBW infants were followed for six weeks after birth with weekly stool collection. DNA was extracted from samples and the V4 region of the 16S rRNA gene was sequenced with Illumina MiSeq. A similar microbiota database from full-term infants was used for comparing gut microbiome and predicted metabolic pathways. The class Gammaproteobacteria increased or remained consistent over time in VLBW infants. Out of 228 metabolic pathways that were significantly different between term and VLBW infants, 133 pathways were significantly lower in VLBW infants. Major metabolic differences in their gut microbiome included pathways involved in decreased glycan biosynthesis and metabolism, reduced biosynthetic capacity, interrupted amino acid metabolism, changes that could result in increased infection susceptibility, and many other system deficiencies. Our study reveals poor postnatal growth in a VLBW cohort who had dysbiotic gut microbiota and differences in predicted metabolic pathways compared to term infants. The gut microbiota in VLBW infants likely plays an important role in postnatal growth. View Full-Text
Keywords: dysbiosis; gut microbiota; gut microbiome metabolic pathway; very low birth weight; growth; NICU dysbiosis; gut microbiota; gut microbiome metabolic pathway; very low birth weight; growth; NICU
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MDPI and ACS Style

Groer, M.; Miller, E.M.; Sarkar, A.; Dishaw, L.J.; Dutra, S.V.; Youn Yoo, J.; Morgan, K.; Ji, M.; Ho, T. Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth. Nutrients 2020, 12, 1345. https://doi.org/10.3390/nu12051345

AMA Style

Groer M, Miller EM, Sarkar A, Dishaw LJ, Dutra SV, Youn Yoo J, Morgan K, Ji M, Ho T. Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth. Nutrients. 2020; 12(5):1345. https://doi.org/10.3390/nu12051345

Chicago/Turabian Style

Groer, Maureen, Elizabeth M. Miller, Anujit Sarkar, Larry J. Dishaw, Samia V. Dutra, Ji Youn Yoo, Katherine Morgan, Ming Ji, and Thao Ho. 2020. "Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth" Nutrients 12, no. 5: 1345. https://doi.org/10.3390/nu12051345

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