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Open AccessArticle

Longitudinal Changes of Mineral Concentrations in Preterm and Term Human Milk from Lactating Swiss Women

1
Nestlé Research, Société des Produits Nestlé SA, 1000 Lausanne, Switzerland
2
Nestle Research Singapore Hub, Société des Produits Nestlé SA, 29 Quality Road, Singapore 618802, Singapore
3
Clinic of Neonatology, Department Woman Mother Child, University Hospital of Lausanne, 1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1855; https://doi.org/10.3390/nu11081855
Received: 15 July 2019 / Revised: 2 August 2019 / Accepted: 6 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Human Milk and Lactation)
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Abstract

An adequate mineral supply to preterm infants is essential for normal growth and development. This study aimed to compare the mineral contents of human milk (HM) from healthy mothers of preterm (28–32 weeks) and full term (>37 weeks) infants. Samples were collected weekly for eight weeks for the term group (n = 34) and, biweekly up to 16 weeks for the preterm group (n = 27). Iron, zinc, selenium, copper, iodine, calcium, magnesium, phosphorus, potassium, and sodium were quantitatively analyzed by Inductively Coupled Plasma-Mass Spectrometry. The mineral contents of both HM showed parallel compositional changes over the period of lactation, with occasional significant differences when compared at the same postpartum age. However, when the comparisons were performed at an equivalent postmenstrual age, preterm HM contained less zinc and copper from week 39 to 48 (p < 0.002) and less selenium from week 39 to 44 (p < 0.002) than term HM. This translates into ranges of differences (min–max) of 53% to 78%, 30% to 72%, and 11% to 33% lower for zinc, copper, and selenium, respectively. These data provide comprehensive information on the temporal changes of ten minerals in preterm HM and may help to increase the accuracy of the mineral fortification of milk for preterm consumption. View Full-Text
Keywords: human milk; term; preterm; calcium; phosphorus; magnesium; zinc; iron; copper; iodine; selenium; potassium; sodium human milk; term; preterm; calcium; phosphorus; magnesium; zinc; iron; copper; iodine; selenium; potassium; sodium
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Sabatier, M.; Garcia-Rodenas, C.L.; De Castro, C.A.; Kastenmayer, P.; Vigo, M.; Dubascoux, S.; Andrey, D.; Nicolas, M.; Richoz Payot, J.; Bordier, V.; Thakkar, S.K.; Beauport, L.; Tolsa, J.-F.; Fischer Fumeaux, C.J.; Affolter, M. Longitudinal Changes of Mineral Concentrations in Preterm and Term Human Milk from Lactating Swiss Women. Nutrients 2019, 11, 1855.

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