Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats

Estruel-Amades, Sheila; Massot-Cladera, Malén; Garcia-Cerdà, Pau; Pérez-Cano, Francisco J.; Franch, Àngels; Castell, Margarida; Camps-Bossacoma, Mariona

doi:10.3390/nu11040783

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Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats

Sheila Estruel-Amades

^1,2

Malén Massot-Cladera

^1,2,

Pau Garcia-Cerdà

^1,2,

Francisco J. Pérez-Cano

^1,2

Àngels Franch

^1,2

Margarida Castell

^1,2,*

and

Mariona Camps-Bossacoma

^1,2

Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain

Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, 08921 Santa Coloma de Gramenet, Spain

Author to whom correspondence should be addressed.

Nutrients 2019, 11(4), 783; https://doi.org/10.3390/nu11040783

Received: 14 March 2019 / Revised: 27 March 2019 / Accepted: 1 April 2019 / Published: 4 April 2019

(This article belongs to the Special Issue Immunomodulation and Nutrition)

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Abstract

Intensive exercise can lead to oxidative stress, which can be particularly deleterious for lymphoid tissues. Hesperidin has demonstrated its antioxidant activity, but few studies focus on its influence on intensive training. The aim of this study was to assess the impact of hesperidin on the oxidant/antioxidant status of lymphoid tissues after an intensive training program. Wistar rats were trained for five weeks (five days per week), including two exhaustion tests plus three trainings per week. During this period, animals were orally administrated with 200 mg/kg of hesperidin or vehicle (three days per week). The oxidative status was determined before, immediately after and 24 h after an additional exhaustion test. The production of reactive oxygen species (ROS) by peritoneal macrophages, superoxide dismutase (SOD) and catalase activities in spleen, thymus and liver, and hepatic glutathione peroxidase activity (GPx) were assessed. Hesperidin prevented an increase in ROS production induced by the additional exhaustion test. Likewise, hesperidin avoided a decrease in SOD and catalase activities in the thymus and spleen that was found after the additional exhaustion test. The antioxidant effects of hesperidin were associated with a higher performance in the assessed training model. These results suggest that hesperidin, acting as an antioxidant, can prevent oxidative stress induced by exercise and improve exercise performance. View Full-Text

Keywords: antioxidant; catalase; exercise; glutathione peroxidase; hesperidin; oxidative stress; ROS; superoxide dismutase; training

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Estruel-Amades, S.; Massot-Cladera, M.; Garcia-Cerdà, P.; Pérez-Cano, F.J.; Franch, À.; Castell, M.; Camps-Bossacoma, M. Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats. Nutrients 2019, 11, 783. https://doi.org/10.3390/nu11040783

AMA Style

Estruel-Amades S, Massot-Cladera M, Garcia-Cerdà P, Pérez-Cano FJ, Franch À, Castell M, Camps-Bossacoma M. Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats. Nutrients. 2019; 11(4):783. https://doi.org/10.3390/nu11040783

Chicago/Turabian Style

Estruel-Amades, Sheila, Malén Massot-Cladera, Pau Garcia-Cerdà, Francisco J. Pérez-Cano, Àngels Franch, Margarida Castell, and Mariona Camps-Bossacoma. 2019. "Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats" Nutrients 11, no. 4: 783. https://doi.org/10.3390/nu11040783

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Protective Effect of Hesperidin on the Oxidative Stress Induced by an Exhausting Exercise in Intensively Trained Rats

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