Fibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndrome
School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
School of Sport and Health Sciences, University of Exeter, Exeter EX4 4PY, UK
Inflammatory Disease Biology and Therapeutics Group/Immunopathology Group, Translational Research Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Queensland 4072, Australia
Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Parkville, Victoria 3010, Australia
K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
SHAPE Research Centre, Exercise Science and Clinical Exercise Physiology, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia 5042, Australia
Author to whom correspondence should be addressed.
Received: 11 March 2019 / Revised: 2 April 2019 / Accepted: 6 April 2019 / Published: 11 April 2019
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The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake,
). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs
= 0.393, p
< 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p
< 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p
< 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes.
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MDPI and ACS Style
Torquati, L.; Coombes, J.S.; Murray, L.; Hasnain, S.Z.; Mallard, A.R.; McGuckin, M.A.; Fassett, R.G.; Croci, I.; Ramos, J.S. Fibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndrome. Nutrients 2019, 11, 815.
Torquati L, Coombes JS, Murray L, Hasnain SZ, Mallard AR, McGuckin MA, Fassett RG, Croci I, Ramos JS. Fibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndrome. Nutrients. 2019; 11(4):815.
Torquati, Luciana; Coombes, Jeff S.; Murray, Lydia; Hasnain, Sumaira Z.; Mallard, Alistair R.; McGuckin, Michael A.; Fassett, Robert G.; Croci, Ilaria; Ramos, Joyce S. 2019. "Fibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndrome." Nutrients 11, no. 4: 815.
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