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Article

Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque

by
Shrikant C. Raut
1,*,
Vinayak W. Patil
1,
Shubhangi M. Dalvi
1 and
Girish D. Bakhshi
2
1
Department of Biochemistry, Grant Government Medical College and Sir JJ Group of Hospitals, Byculla, Mumbai, India
2
Department of Surgery, Grant Government Medical College and Sir JJ Group of Hospitals, Byculla, Mumbai, India
*
Author to whom correspondence should be addressed.
Clin. Pract. 2015, 5(1), 717; https://doi.org/10.4081/cp.2015.717
Submission received: 14 October 2014 / Revised: 19 January 2015 / Accepted: 2 February 2015 / Published: 30 March 2015

Abstract

Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP) but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the earliest event in the process of atherosclerosis and plaque formation. Retrospective study conducted at tertiary care hospital in Mumbai by Department of Biochemistry in association with Department of Surgery. Eighty patients who underwent gastroscopy in view of gastritis were subjected to rapid urease test for diagnosis of H. pylori infection. Vitamin B12, folic acid, homocysteine and hs-CRP were analyzed using chemiluminescence immuno assay. Student’s t-test, Pearson’s correlation and linear regression used for statistical analysis. Patients with H. pylori gastritis had significantly lower levels of vitamin B12 (271.6 ± 101.3 vs. 390.6 ± 176.7 pg/mL; P = 0.0005), as well as higher levels of homocysteine (17.4 ± 7.4 vs. 13.8 ± 7.8 mmol/L; P = 0.037) and hs-CRP (2.5 ± 2.9 vs. 1.2 ± 1.1 mg/L; P = 0.017), than in patients without H. pylori gastritis. However, folic acid showed (8.9 ± 3.2 vs. 10.0 ± 3.6 ng/mL; P = 0.171) no significant difference. Elevated homocysteine and hs-CRP in H. pylori gastritis may independently induce endothelial dysfunction, leading to cardiovascular pathology.
Keywords: Helicobacter pylori; cardiovascular disease; homocysteine; C-reactive protein; vitamin B12; chemiluminescence Helicobacter pylori; cardiovascular disease; homocysteine; C-reactive protein; vitamin B12; chemiluminescence

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MDPI and ACS Style

Raut, S.C.; Patil, V.W.; Dalvi, S.M.; Bakhshi, G.D. Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque. Clin. Pract. 2015, 5, 717. https://doi.org/10.4081/cp.2015.717

AMA Style

Raut SC, Patil VW, Dalvi SM, Bakhshi GD. Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque. Clinics and Practice. 2015; 5(1):717. https://doi.org/10.4081/cp.2015.717

Chicago/Turabian Style

Raut, Shrikant C., Vinayak W. Patil, Shubhangi M. Dalvi, and Girish D. Bakhshi. 2015. "Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque" Clinics and Practice 5, no. 1: 717. https://doi.org/10.4081/cp.2015.717

APA Style

Raut, S. C., Patil, V. W., Dalvi, S. M., & Bakhshi, G. D. (2015). Helicobacter pylori Gastritis, a Presequeale to Coronary Plaque. Clinics and Practice, 5(1), 717. https://doi.org/10.4081/cp.2015.717

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